With the rise in obesity worldwide, an important debate has developed as to whether excess
fat has a detrimental or protective effect on skeletal health in children and adults. Obese …

A complex interplay of genetic, environmental, hormonal, and behavioral factors affect
skeletal development, several of which are associated with childhood fractures. Given the …

Osteoporosis and obesity are both major public health concerns. It has long been
considered that these are distinct disorders rarely found in the same individual; however …

Increased risk of fracture identified in obese children has led to a focus on the relationship
between fat, bone, and the impact of obesity during skeletal development. Early studies …

Fat mass predicts bone accrual in prepubertal children, but obese children have increased
fracture risk. We hypothesised that bone size and mass would vary according to prior …

Body weight impacts both bone turnover and bone density, making it, therefore, an important
risk factor for vertebral and hip fractures and ranking it alongside age in importance. The …

Excess adiposity in childhood may affect bone development, ultimately leading to bone
frailty. Previous reports showing an increased rate of extremity fractures in children with …

Context: Fat mass represents a positive influence on bone mass in adults, independently of
other factors such as lean mass, but whether a similar action occurs in children is unclear …

Infancy and adolescence are crucial periods for bone health, since they are characterized by
intense physical growth and bone development. The unsatisfactory acquisition of bone mass …

It was previously believed that obesity and osteoporosis were two unrelated diseases, but
recent studies have shown that both diseases share several common genetic and …