The reticuloendothelial system plays a major role in iron metabolism. Despite this, the
manner in which macrophages handle iron remains poorly understood. Mammalian cells …

A majority of cells obtain of transferrin (Tf) bound iron via transferrin receptor 1 (TfR1) or by
transferrin receptor 2 (TfR2) in hepatocytes. Our study establishes that cells are capable of …

BACKGROUND: The long held view is that mammalian cells obtain transferrin (Tf) bound
iron utilizing specialized membrane anchored receptors. Here we report that, during …

The posttranslational regulation of transferrin receptor (TfR1) is largely unknown. We
investigated whether iron availability affects TfR1 endocytic cycle and protein stability in …

HFE, the protein that is mutated in hereditary haemochromatosis, binds to the transferrin
receptor (TfR). Here we show that wild-type HFE and TfR localize in endosomes and at the …

Abstract The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-
dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis …

Transferrin receptor-2 is a transmembrane protein whose expression is restricted to
hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron …

ABSTRACT Iron (Fe2+, Fe3+) homeostasis is a tightly regulated process, involving precise
control of iron influx and egress from cells. Although the mechanisms of its import into cells …

Fine-tuning of body iron is required to prevent diseases such as iron-overload and anemia.
The putative iron sensor, transferrin receptor 2 (TfR2), is expressed in the liver and …

Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1), the protein that
delivers iron to cells through receptor-mediated endocytosis of diferric transferrin (Fe2Tf) …