[PDF][PDF] BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair
The mechanisms contributing to transcription-associated genomic instability are both
complex and incompletely understood. Although R-loops are normal transcriptional …
complex and incompletely understood. Although R-loops are normal transcriptional …
The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection
KA Coleman, RA Greenberg - Journal of Biological Chemistry, 2011 - ASBMB
The tumor suppressor protein BRCA1 is a constituent of several different protein complexes
and is required for homology-directed repair (HDR) of DNA double strand breaks (DSBs) …
and is required for homology-directed repair (HDR) of DNA double strand breaks (DSBs) …
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage
BRCA1 is a breast and ovarian tumor suppressor. Given its numerous incompletely
understood functions and the possibility that more exist, we performed complementary …
understood functions and the possibility that more exist, we performed complementary …
Roles of BRCA1 in DNA damage repair: a link between development and cancer
CX Deng, RH Wang - Human molecular genetics, 2003 - academic.oup.com
DNA damage causes devastating problems for developing organisms. Recent studies
reveal that BRCA1 plays essential roles in homologous recombinational repair, non …
reveal that BRCA1 plays essential roles in homologous recombinational repair, non …
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
X Zhang, HC Chiang, Y Wang, C Zhang, S Smith… - Nature …, 2017 - nature.com
Most BRCA1-associated breast tumours are basal-like yet originate from luminal
progenitors. BRCA1 is best known for its functions in double-strand break repair and …
progenitors. BRCA1 is best known for its functions in double-strand break repair and …
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks
LJ Reid, R Shakya, AP Modi… - Proceedings of the …, 2008 - National Acad Sciences
Hereditary cases of breast and ovarian cancer are often attributed to germ-line mutations of
the BRCA1 tumor suppressor gene. Although BRCA1 is involved in diverse cellular …
the BRCA1 tumor suppressor gene. Although BRCA1 is involved in diverse cellular …
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
We report the identities of the members of a group of proteins that associate with BRCA1 to
form a large complex that we have named BASC (B RCA1-a ssociated genome s urveillance …
form a large complex that we have named BASC (B RCA1-a ssociated genome s urveillance …
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells
Cumulative evidence indicates that breast cancer-associated gene 1 (BRCA1) participates
in DNA damage repair and cell-cycle checkpoint control, serving as a tumor susceptibility …
in DNA damage repair and cell-cycle checkpoint control, serving as a tumor susceptibility …
BRCA1 haploinsufficiency for replication stress suppression in primary cells
S Pathania, S Bade, M Le Guillou, K Burke… - Nature …, 2014 - nature.com
BRCA1—a breast and ovarian cancer suppressor gene—promotes genome integrity. To
study the functionality of BRCA1 in the heterozygous state, we established a collection of …
study the functionality of BRCA1 in the heterozygous state, we established a collection of …
Good timing in the cell cycle for precise DNA repair by BRCA1
ST Durant, JA Nickoloff - Cell Cycle, 2005 - Taylor & Francis
It is now clear that large DNA-binding proteins have evolved in mammals to orchestrate the
relatively ancient processes of DNA recombinational repair. These proteins are recruited to …
relatively ancient processes of DNA recombinational repair. These proteins are recruited to …