Immune System Dysregulation in the Progression of Multiple Sclerosis: Molecular Insights and Therapeutic Implications

Z Khan, S Mehan, GD Gupta, AS Narula - Neuroscience, 2024 - Elsevier
Multiple sclerosis (MS), a prevalent neurological disorder, predominantly affects young
adults and is characterized by chronic autoimmune activity. The study explores the immune …

Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

M Charabati, MA Wheeler, HL Weiner, FJ Quintana - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

[HTML][HTML] Recent advances in understanding multiple sclerosis

PK Stys, S Tsutsui - F1000Research, 2019 - ncbi.nlm.nih.gov
Emerging data point to important contributions of both autoimmune inflammation and
progressive degeneration in the pathophysiology of multiple sclerosis (MS). Unfortunately …

Modulating inflammation and neuroprotection in multiple sclerosis

H Yong, G Chartier, J Quandt - Journal of Neuroscience …, 2018 - Wiley Online Library
Multiple sclerosis (MS) is a neurological disorder of the central nervous system with a
presentation and disease course that is largely unpredictable. MS can cause loss of …

The immunology of multiple sclerosis

KE Attfield, LT Jensen, M Kaufmann… - Nature Reviews …, 2022 - nature.com
Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis

G Mallucci, L Peruzzotti-Jametti, JD Bernstock… - Progress in …, 2015 - Elsevier
Multiple sclerosis is one of the most common causes of chronic neurological disability
beginning in early to middle adult life. Multiple sclerosis is idiopathic in nature, yet …

Toward the development of rational therapies in multiple sclerosis: what is on the horizon?

B Hemmer, HP Hartung - Annals of neurology, 2007 - Wiley Online Library
Although the cause of multiple sclerosis (MS) has remained obscure, many findings support
an autoimmune pathogenesis on the background of a complex interaction between multiple …

Remyelination pharmacotherapy investigations highlight diverse mechanisms underlying multiple sclerosis progression

GS Melchor, T Khan, JF Reger… - ACS Pharmacology & …, 2019 - ACS Publications
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system
characterized by a complex lesion microenvironment. Although much progress has been …

The immunopathophysiology of multiple sclerosis

GF Wu, E Alvarez - Neurologic clinics, 2011 - neurologic.theclinics.com
The cause of multiple sclerosis (MS) is elusive. However, clues to the pathogenesis of this
condition have traditionally been derived from the basic pathologic characterization of the …

The immune response in multiple sclerosis

S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …