Cutaneous science has seen considerable development in the last 25 years, in part due to
the Omics revolution, and the appreciation that this organ is hardwired into the body's key …

Aging is a complex process that defines changes observed throughout the organism's life
span. It represents a biologic attrition at the cellular level, resulting in decreased reserve …

Aging can be defined as a state of progressive functional decline accompanied by an
increase in mortality. Time-dependent accumulation of cellular damage, namely lesions and …

Here we aim to describe each factor that leads to skin aging and describe their mechanisms.
A PubMed database searches (from January 2004 to March 2014) using aging and skin as …

Skin aging is a complex biologic process influenced by a combination of intrinsic and
extrinsic factors. Aging skin shows wrinkles, uneven tone, loss of elasticity, and thinning …

Skin appearance is a primary indicator of age. During the last decade, substantial progress
has been made toward understanding underlying mechanisms of human skin aging. This …

Skin aging is characterized by changes in its structural, cellular, and molecular components
in both the epidermis and dermis. Dermal aging is distinguished by reduced dermal …

Skin aging is accompanied by a gradual loss of function, physiological integrity and the
ability to cope with internal and external stressors. This is secondary to a combination of …

As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …

Skin aging appears to be the result of two overlapping processes, intrinsic and extrinsic. It is
well accepted that oxidative stress contributes significantly to extrinsic skin aging, although …