With worldwide expansion of the aging population, research on age-related pathologies is
receiving growing interest. In this review, we discuss current knowledge regarding the …

Similar to the entire organism, skin is subject to an unpreventable intrinsic ageing process.
Additionally, skin ageing is also influenced by exogenous factors. Ultraviolet radiation in …

One of the major challenges of the 21 st century is the fight against aging, defined as a set of
physiological mechanisms altering the physical and intellectual capacities of human beings …

Cellular senescence and aging result in a reduced ability to manage persistent types of
inflammation. Thus, the chronic low-level inflammation associated with aging phenotype is …

Collagen and elastin networks make up the majority of the extracellular matrix in many
organs, such as the skin. The mechanisms which are involved in the maintenance of …

In developed countries, interest in cutaneous aging is in large part the result of a
progressive, dramatic rise over the past century in the absolute number and the proportion of …

This article reviews glycation stress as a factor linked to age-related diseases and functional
and structural alterations of the skin. Photo-aging and glycation stress are major causes of …

The outward manifestations of tissue ageing occurring in the elderly primarily involve the two
major structural proteins of the body, collagen and elastin. The changes in these proteins …

Inflammaging and immunosenescence are associated with aging of the human body, but
there are key differences between them. Immunosenescence aims to adapt the body …

Sun‐exposed skin is characterized by superficial changes such as wrinkles, sagging and
pigmentary changes, and also many internal changes in the structure and function of …