Autophagy: an overview and its roles in cancer and obesity

JA Jacob, JMM Salmani, Z Jiang, L Feng, J Song… - Clinica chimica acta, 2017 - Elsevier
Autophagy is a normal physiological process necessary for cellular homeostasis to maintain
adequate levels of cellular components. It is essential to stabilize the source of energy …

Role of autophagy in cancer prevention, development and therapy

GV Helgason, TL Holyoake, KM Ryan - Essays in biochemistry, 2013 - portlandpress.com
Autophagy is a process that takes place in all mammalian cells and ensures homoeostasis
and quality control. The term autophagy [self (auto)-eating (phagy)] was first introduced in …

[HTML][HTML] Dual roles of autophagy and their potential drugs for improving cancer therapeutics

DW Shin - Biomolecules & Therapeutics, 2020 - ncbi.nlm.nih.gov
Autophagy is a major catabolic process that maintains cell metabolism by degrading
damaged organelles and other dysfunctional proteins via the lysosome. Abnormal …

Autophagy: The spotlight for cellular stress responses

P Ravanan, IF Srikumar, P Talwar - Life sciences, 2017 - Elsevier
Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

Chaperone-mediated autophagy is required for tumor growth

M Kon, R Kiffin, H Koga, J Chapochnick… - Science translational …, 2011 - science.org
The cellular process of autophagy (literally “self-eating”) is important for maintaining the
homeostasis and bioenergetics of mammalian cells. Two of the best-studied mechanisms of …

[HTML][HTML] Autophagy dysfunctions associated with cancer cells and their therapeutic implications

A Udristioiu, D Nica-Badea - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Genomic analysis of human cancers indicates that the loss or mutation of core autophagy
related genes,(ATG) is uncommon, whereas oncogenic events that activate autophagy and …

Autophagy and cancer

HE Karakaş, D GÖZÜAÇIK - Turkish Journal of Biology, 2014 - journals.tubitak.gov.tr
Autophagy is an evolutionary conserved intracellular degradation and stress response
mechanism that is mainly responsible for the breakdown and recycling of cytoplasmic …

Autophagy paradox of cancer: Role, regulation, and duality

AK Verma, PS Bharti, S Rafat, D Bhatt… - Oxidative Medicine …, 2021 - Wiley Online Library
Autophagy, a catabolic process, degrades damaged and defective cellular materials through
lysosomes, thus working as a recycling mechanism of the cell. It is an evolutionarily …

Molecular mechanisms of autophagy in cancer development, progression, and therapy

VAM Vitto, S Bianchin, AA Zolondick, G Pellielo… - Biomedicines, 2022 - mdpi.com
Autophagy is an evolutionarily conserved and tightly regulated process that plays an
important role in maintaining cellular homeostasis. It involves regulation of various genes …

[HTML][HTML] Unfolding the role of autophagy in the cancer metabolism

A Pandey, P Yadav, S Shukla - Biochemistry and Biophysics Reports, 2021 - Elsevier
Autophagy is considered an indispensable process that scavenges toxins, recycles complex
macromolecules, and sustains the essential cellular functions. In addition to its …