Effect of gene-expression bursts on stochastic timing of cellular events

KR Ghusinga, A Singh - 2017 American Control Conference …, 2017 - ieeexplore.ieee.org
Gene expression is inherently a noisy process which manifests as cell-to-cell variability in
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …

First-passage time calculations for a gene expression model

KR Ghusinga, A Singh - 53rd IEEE Conference on Decision …, 2014 - ieeexplore.ieee.org
The stochastic nature of gene expression can lead to significant cell-to-cell variability in the
time at which a certain protein level is attained. This is reflected in the timing of cellular …

Optimal auto-regulation to minimize first-passage time variability in protein level

KR Ghusinga, PW Fok, A Singh - 2015 American Control …, 2015 - ieeexplore.ieee.org
The timing of cellular events is inherently random because of the probabilistic nature of gene
expression. Yet cells manage to have precise timing of important events. Here, we study …

Theoretical predictions on the first-passage time for a gene expression model

KR Ghusinga, A Singh - 2015 54th IEEE Conference on …, 2015 - ieeexplore.ieee.org
Expression of a gene is inherently random, leading to variability in a protein's level across a
population of cells with same genetic information and environment. Another consequence of …

Optimal regulation of protein degradation to schedule cellular events with precision

KR Ghusinga, A Singh - 2016 American Control Conference …, 2016 - ieeexplore.ieee.org
An important event in many cellular contexts is the crossing of a prescribed threshold by a
regulatory protein. The timing of such events is stochastic as a consequence of the innate …

Analysis of stochastic timing of intracellular events with gene switching

KR Ghusinga, A Singh - 2019 Sixth Indian Control Conference …, 2019 - ieeexplore.ieee.org
An important step in execution of several cellular processes is accumulation of a regulatory
protein up to a specific threshold level. Since production of a protein is inherently stochastic …

Control strategies for the timing of intracellular events

M Cao, B Qiu, T Zhou, J Zhang - Physical Review E, 2019 - APS
While the timing of intracellular events is essential for many cellular processes, gene
expression inside a single cell can exhibit substantial cell-to-cell variability, raising the …

Estimation of mean first passage time for bursty gene expression

M Shreshtha, A Surendran, A Ghosh - Physical biology, 2016 - iopscience.iop.org
Gene expression is an intrinsically noisy process, typically, producing mRNAs and proteins
in bursts. An important description of such stochastic processes can be done in terms of the …

[HTML][HTML] Modulation of first-passage time for bursty gene expression via random signals

Q Li, L Huang, J Yu - Mathematical Biosciences & Engineering, 2017 - aimsciences.org
The stochastic nature of cell-specific signal molecules (such as transcription factor,
ribosome, etc.) and the intrinsic stochastic nature of gene expression process result in cell-to …

Feedback strategies for threshold crossing of protein levels at a prescribed time

C Nieto, KR Ghusinga, A Singh - 2022 30th Mediterranean …, 2022 - ieeexplore.ieee.org
The timing of diverse cellular processes is based on the instant when the concentration of
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …