Effect of gene-expression bursts on stochastic timing of cellular events
KR Ghusinga, A Singh - 2017 American Control Conference …, 2017 - ieeexplore.ieee.org
Gene expression is inherently a noisy process which manifests as cell-to-cell variability in
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …
First-passage time calculations for a gene expression model
KR Ghusinga, A Singh - 53rd IEEE Conference on Decision …, 2014 - ieeexplore.ieee.org
The stochastic nature of gene expression can lead to significant cell-to-cell variability in the
time at which a certain protein level is attained. This is reflected in the timing of cellular …
time at which a certain protein level is attained. This is reflected in the timing of cellular …
Optimal auto-regulation to minimize first-passage time variability in protein level
The timing of cellular events is inherently random because of the probabilistic nature of gene
expression. Yet cells manage to have precise timing of important events. Here, we study …
expression. Yet cells manage to have precise timing of important events. Here, we study …
Theoretical predictions on the first-passage time for a gene expression model
KR Ghusinga, A Singh - 2015 54th IEEE Conference on …, 2015 - ieeexplore.ieee.org
Expression of a gene is inherently random, leading to variability in a protein's level across a
population of cells with same genetic information and environment. Another consequence of …
population of cells with same genetic information and environment. Another consequence of …
Optimal regulation of protein degradation to schedule cellular events with precision
KR Ghusinga, A Singh - 2016 American Control Conference …, 2016 - ieeexplore.ieee.org
An important event in many cellular contexts is the crossing of a prescribed threshold by a
regulatory protein. The timing of such events is stochastic as a consequence of the innate …
regulatory protein. The timing of such events is stochastic as a consequence of the innate …
Analysis of stochastic timing of intracellular events with gene switching
KR Ghusinga, A Singh - 2019 Sixth Indian Control Conference …, 2019 - ieeexplore.ieee.org
An important step in execution of several cellular processes is accumulation of a regulatory
protein up to a specific threshold level. Since production of a protein is inherently stochastic …
protein up to a specific threshold level. Since production of a protein is inherently stochastic …
Control strategies for the timing of intracellular events
M Cao, B Qiu, T Zhou, J Zhang - Physical Review E, 2019 - APS
While the timing of intracellular events is essential for many cellular processes, gene
expression inside a single cell can exhibit substantial cell-to-cell variability, raising the …
expression inside a single cell can exhibit substantial cell-to-cell variability, raising the …
Estimation of mean first passage time for bursty gene expression
Gene expression is an intrinsically noisy process, typically, producing mRNAs and proteins
in bursts. An important description of such stochastic processes can be done in terms of the …
in bursts. An important description of such stochastic processes can be done in terms of the …
[HTML][HTML] Modulation of first-passage time for bursty gene expression via random signals
Q Li, L Huang, J Yu - Mathematical Biosciences & Engineering, 2017 - aimsciences.org
The stochastic nature of cell-specific signal molecules (such as transcription factor,
ribosome, etc.) and the intrinsic stochastic nature of gene expression process result in cell-to …
ribosome, etc.) and the intrinsic stochastic nature of gene expression process result in cell-to …
Feedback strategies for threshold crossing of protein levels at a prescribed time
The timing of diverse cellular processes is based on the instant when the concentration of
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …
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