Novel roles for chemokines and fibroblasts in interstitial fibrosis. Background Regardless of
its involvement in either wound healing or excessive fibrosis, the interstitial fibroblast can …

Renal inflammation is the initial, healthy response to renal injury. However, prolonged
inflammation promotes the fibrosis process, which leads to chronic pathology and eventually …

Tubulointerstitial fibrosis is an obligate finding in end-stage diseased kidneys. Renal fibrosis
is defined as excessive matrix deposition that leads to tissue destruction and impairment of …

Renal cortical fibroblasts have key roles in mediating intercellular communication with
neighboring/infiltrating cells and extracellular matrix (ECM) and maintenance of renal tissue …

Obstructive nephropathy is a major cause of renal failure, particularly in newborn babies and
children. After urinary tract obstruction, and under the influence of mechanical forces and …

Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an
independent predictor of disease progression. Deposition of pathological matrix in the walls …

Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Fibrocytes are supposed to be a circulating connective tissue cell progenitor, which consists
of a novel population of peripheral blood cells. This distinct population of blood-borne cells …

Interstitial fibrosis is a common feature of chronic kidney disease, regardless of the etiology
of the primary renal syndrome. Moreover, interstitial fibrosis is the strongest morphologic …

Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of
pathological matrix in the interstitial space and within the walls of glomerular capillaries as …