Natural and de novo designed peptides are gaining an ever-growing interest as drugs
against several diseases. Their use is however limited by the intrinsic low bioavailability and …

Retroinverso analog of a natural polypeptide can sometimes mimic the structure and
function of the natural peptide. The additional advantage of using retroinverso analog is that …

Main-chain peptidomimetics based on peptide-bond reversal and inversion of chirality
represent important structural alterations for peptides and proteins, and are highly significant …

Physiological processes are regulated to a large extent by physical and chemical
interactions between polypeptides. Although many small molecules have been discovered …

Peptides are experiencing a new era in medical research, finding applications ranging from
therapeutics to vaccines. In spite of the promising properties of peptide pharmaceuticals …

Twelve years ago we published an Account in which we presented a stereochemical
analysis of cyclic and linear retro-peptide systems. 1 We postulated that reversal of peptide …

Peptides have great potential as therapeutic agents, but their use is often limited by
susceptibility to proteolysis and their resulting in vivo fragility. In this review, we focus on …

Biologics are a rapidly growing class of therapeutics with many advantages over traditional
small molecule drugs. A major obstacle to their development is that proteins and peptides …

Peptide side chains play critical roles in the event of molecular recognition. In order to study
the bioactive conformation of parent peptides, a concise and straightforward five-step …

This review provides a fresh overview of non-canonical amino acids and their applications in
the design of peptidomimetics. Non-canonical amino acids appear widely distributed in …