[HTML][HTML] Pyridoxamine improves survival and limits cardiac dysfunction after MI
D Deluyker, V Ferferieva, RB Driesen, M Verboven… - Scientific Reports, 2017 - nature.com
Advanced glycation end products (AGEs) play a key role in the progression of heart failure.
Whether treatments limiting AGEs formation would prevent adverse left ventricular …
Whether treatments limiting AGEs formation would prevent adverse left ventricular …
Pyridoxamine Reverts Methylglyoxal‐induced Impairment of Survival Pathways During Heart Ischemia
F Almeida, D Santos‐Silva, T Rodrigues… - Cardiovascular …, 2013 - Wiley Online Library
Background and aims Increased levels of advanced glycation end‐products (AGE) and their
precursors, such as methylglyoxal (MG), in patients with diabetes may account for impaired …
precursors, such as methylglyoxal (MG), in patients with diabetes may account for impaired …
Pyridoxamine protects against mechanical defects in cardiac ageing in rats: studies on load dependence of myocardial relaxation
CH Wang, ET Wu, MS Wu, MS Tsai… - Experimental …, 2014 - Wiley Online Library
New Findings What is the central question of this study? This study aimed to investigate the
hypothesis that pyridoxamine, one of the three natural forms of vitamin B6, can protect …
hypothesis that pyridoxamine, one of the three natural forms of vitamin B6, can protect …
Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction
NJR Blackburn, B Vulesevic, B McNeill… - Basic research in …, 2017 - Springer
Advanced glycation end-products (AGEs) have been associated with poorer outcomes after
myocardial infarction (MI), and linked with heart failure. Methylglyoxal (MG) is considered the …
myocardial infarction (MI), and linked with heart failure. Methylglyoxal (MG) is considered the …
[HTML][HTML] Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels
DJ Campbell, JB Somaratne, AJ Jenkins, DL Prior… - PLoS …, 2012 - journals.plos.org
Background Heart failure is associated with abnormalities of myocardial structure, and
plasma levels of the advanced glycation end-product (AGE) Nε-(carboxymethyl) lysine …
plasma levels of the advanced glycation end-product (AGE) Nε-(carboxymethyl) lysine …
Abundance, localization, and functional correlates of the advanced glycation end‐product carboxymethyl lysine in human myocardium
MM LeWinter, D Taatjes, T Ashikaga… - Physiological …, 2017 - Wiley Online Library
Advanced glycation end‐products (AGE s) play a role in the pathophysiology of diabetes
mellitus (DM) and possibly hypertension (HTN). In experimental DM, AGE s accumulate in …
mellitus (DM) and possibly hypertension (HTN). In experimental DM, AGE s accumulate in …
Combined methylglyoxal scavenger and collagen hydrogel therapy prevents adverse remodeling and improves cardiac function post‐myocardial infarction
CE Cimenci, NJR Blackburn… - Advanced Functional …, 2022 - Wiley Online Library
Methylglyoxal (MG) is a highly reactive dicarbonyl and the main precursor of advanced
glycation end‐products (AGEs). After myocardial infarction (MI), MG‐derived AGEs …
glycation end‐products (AGEs). After myocardial infarction (MI), MG‐derived AGEs …
Recombinant human collagen hydrogel rapidly reduces methylglyoxal adducts within cardiomyocytes and improves borderzone contractility after myocardial infarction …
S McLaughlin, V Sedlakova, Q Zhang… - Advanced Functional …, 2022 - Wiley Online Library
Methylglyoxal (MG) production after myocardial infarction (MI) leads to advanced glycation
end‐product formation, adverse remodeling, and loss of cardiac function. The extracellular …
end‐product formation, adverse remodeling, and loss of cardiac function. The extracellular …
Pharmacological modulation of cardiac remodeling after myocardial infarction
W Zhao, J Zhao, J Rong - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Cardiac remodeling describes a series of structural and functional changes in the heart after
myocardial infarction (MI). Adverse post‐MI cardiac remodeling directly jeopardizes the …
myocardial infarction (MI). Adverse post‐MI cardiac remodeling directly jeopardizes the …
Cross-linking versus RAGE: How do high molecular weight advanced glycation products induce cardiac dysfunction?
D Deluyker, V Ferferieva, JP Noben, Q Swennen… - International Journal of …, 2016 - Elsevier
Background Several clinical and experimental studies have demonstrated that advanced
glycation end products (AGEs) are associated with adverse cardiac outcome. Growing …
glycation end products (AGEs) are associated with adverse cardiac outcome. Growing …