Uterine leiomyoma stem cells: linking progesterone to growth
SE Bulun, MB Moravek, P Yin, M Ono… - Seminars in …, 2015 - thieme-connect.com
Uterine leiomyomas (fibroids) represent the most common class of benign tumors in women.
Multiple leiomyomas usually arise from the uterus of a symptomatic woman. These tumors …
Multiple leiomyomas usually arise from the uterus of a symptomatic woman. These tumors …
Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth
M Ono, P Yin, A Navarro, MB Moravek… - Proceedings of the …, 2013 - National Acad Sciences
Uterine leiomyomas are extremely common estrogen and progesterone-dependent tumors
of the myometrium and cause irregular uterine bleeding, severe anemia, and recurrent …
of the myometrium and cause irregular uterine bleeding, severe anemia, and recurrent …
Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications
MB Moravek, P Yin, M Ono, JS Coon V… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Uterine leiomyoma is the most common benign tumor in women and is
thought to arise from the clonal expansion of a single myometrial smooth muscle cell …
thought to arise from the clonal expansion of a single myometrial smooth muscle cell …
[PDF][PDF] Stem cells and uterine leiomyomas: What is the evidence
MM Carneiro - JBRA Assist Reprod, 2016 - researchgate.net
Uterine leiomyomas, also known as uterine fibroids or uterine myomas, are the most
common benign gynecologic tumors found in women of reproductive age. In spite of the …
common benign gynecologic tumors found in women of reproductive age. In spite of the …
Tissue-specific stem cells in the myometrium and tumor-initiating cells in leiomyoma
M Ono, SE Bulun, T Maruyama - Biology of reproduction, 2014 - academic.oup.com
Tissue-specific (or somatic) stem cells constitute a subset of cells residing in normal adult
tissues. By undergoing asymmetric division, they retain their ability to self-renew while …
tissues. By undergoing asymmetric division, they retain their ability to self-renew while …
The role of progesterone signaling in the pathogenesis of uterine leiomyoma
JJ Kim, EC Sefton - Molecular and cellular endocrinology, 2012 - Elsevier
Uterine leiomyomas are benign tumors that originate from the myometrium. Evidence points
to ovarian steroid hormones, in particular, progesterone as major promoters of leiomyoma …
to ovarian steroid hormones, in particular, progesterone as major promoters of leiomyoma …
Molecular and cellular insights into the development of uterine fibroids
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …
Role of stem cells in human uterine leiomyoma growth
M Ono, W Qiang, VA Serna, P Yin, JS Coon, A Navarro… - PloS one, 2012 - journals.plos.org
Background Uterine leiomyoma is the most common benign tumor in reproductive-age
women. Each leiomyoma is thought to be a benign monoclonal tumor arising from a single …
women. Each leiomyoma is thought to be a benign monoclonal tumor arising from a single …
Uterine leiomyoma: new perspectives on an old disease
JH Segars, A Al-Hendy - Seminars in reproductive medicine, 2017 - thieme-connect.com
Uterine leiomyomas (fibroids) have afflicted women since antiquity, as evidenced by the
calcified fibroids detected from the remains of cave women and Egyptian mummies. Though …
calcified fibroids detected from the remains of cave women and Egyptian mummies. Though …
[PDF][PDF] Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target
Uterine leiomyoma (LM) is the most common tumor in women. Via its receptor (PGR)
expressed in differentiated LM cells, progesterone stimulates paracrine signaling that …
expressed in differentiated LM cells, progesterone stimulates paracrine signaling that …
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