Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor

SL Sandow, M Tare, HA Coleman, CE Hill… - Circulation …, 2002 - Am Heart Assoc
The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is
controversial, putatively involving diffusible factors and/or electrotonic spread of …

Incidence of myoendothelial gap junctions in the proximal and distal mesenteric arteries of the rat is suggestive of a role in endothelium-derived hyperpolarizing factor …

SL Sandow, CE Hill - Circulation research, 2000 - Am Heart Assoc
Although the chemical nature of endothelium-derived hyperpolarizing factor (EDHF) remains
elusive, electrophysiological evidence exists for electrical communication between smooth …

[HTML][HTML] Endothelium-Derived Hyperpolarizing Factor and Myoendothelial Coupling: The in vivo Perspective

K Schmidt, C De Wit - Frontiers in Physiology, 2020 - frontiersin.org
The endothelium controls vascular tone adopting blood flow to tissue needs. It releases
chemical mediators [eg, nitric oxide (NO), prostaglandins (PG)] and exerts appreciable …

Factors, fiction and endothelium‐derived hyperpolarizing factor

SL Sandow - Clinical and Experimental Pharmacology and …, 2004 - Wiley Online Library
The principal mediators of vascular tone are neural, endothelial and physical stimuli that
result in the initiation of dilator and constrictor responses to facilitate the control of blood …

Endothelium-derived hyperpolarizing factor: where are we now?

M Félétou, PM Vanhoutte - Arteriosclerosis, thrombosis, and …, 2006 - Am Heart Assoc
The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

Endothelium‐dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?

TM Griffith - British journal of pharmacology, 2004 - Wiley Online Library
An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …

Pentobarbital-sensitive EDHF comediates ACh-induced arteriolar dilation in the hamster microcirculation

C de Wit, N Esser, HA Lehr… - American Journal of …, 1999 - journals.physiology.org
It is unclear to what extent the endothelium-derived hyperpolarizing factor (EDHF)
contributes to the control of microcirculatory blood flow in vivo. We analyzed, by intravital …

Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery

SL Sandow, K Goto, NM Rummery… - The Journal of …, 2004 - Wiley Online Library
A role for myoendothelial gap junctions (MEGJs) has been proposed in the action of the
vasodilator endothelium‐derived hyperpolarizing factor (EDHF). EDHF activity varies in …

Contribution of endothelium‐derived hyperpolarizing factors to the regulation of vascular tone in humans

J Bellien, C Thuillez… - Fundamental & clinical …, 2008 - Wiley Online Library
Endothelium plays a crucial role in the regulation of cardiovascular homeostasis through the
release of vasoactive factors. Besides nitric oxide (NO) and prostacyclin, increasing …

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans

T Matoba, H Shimokawa - Journal of pharmacological sciences, 2003 - jstage.jst.go.jp
Vascular endothelium plays an important role in maintaining vascular homeostasis by
synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide …