Background and Purpose—Inspired from preconditioning studies, ischemic
postconditioning, consisting of the application of intermittent interruptions of blood flow …

Sublethal periods of hypoxia or ischemia can induce adaptive mechanisms to protect
against subsequent lethal ischemic insults in a process known as ischemic preconditioning …

Background and Purpose—Hypoxic preconditioning is an endogenous protection against
subsequent lethal hypoxia, but the mechanism involved is not understood. Hypoxia is …

Previous studies have demonstrated the protective effect of hypoxic preconditioning on
acute cerebral infarction, but the mechanisms underlying this protection remain unclear. To …

Objective: Brief systemic hypoxia protects the rodent brain from subsequent ischemic injury,
although the protection wanes within days. We hypothesized that the duration of ischemic …

Ischemic postconditioning, a series of mechanical interruptions of blood flow immediately
after reperfusion, has been described in brain studies. However, hypoxic postconditioning …

Background and Purpose—Ischemic postconditioning has been found to decrease brain
infarct area and spinal cord ischemic injury. In this study, we tested the hypothesis that …

Tolerance to cerebral ischemia is achieved by preconditioning sublethal stresses, such as
ischemia or hypoxia, paradigms in which the decrease of O2 availability may constitute an …

As clinical trials of pharmacological neuroprotective strategies in stroke have been
disappointing, attention has turned to the brain's own endogenous strategies for …

In cerebral ischemic preconditioning (IPC), a first sublethal ischemia increases the
resistance of neurons to a subsequent severe ischemia. Despite numerous studies, the …