Background and objective: Discussing population-based cancer risk and screening is
common in general practice. Patients with an inherited cancer syndrome, however, may …

Abstract Li–Fraumeni syndrome (LFS), a rare cancer syndrome caused by pathogenic
germline variants in TP53, has serious implications for adolescents and young adults (AYAs; …

Purpose This study explored the genetic testing experiences of adolescents and young
adults (AYAs; aged 15–39 years) with, or at 50% risk of, an early onset cancer predisposition …

Estimates of the number of childhood cancers with a genetic basis range from 5–8.5% found
in germline samples to 29% based on clinical criteria. Family history-taking practice is a …

Introduction: cancer is the second leading cause of death in children between the ages of 0
and 14 years, corresponding to approximately 3% of all cases diagnosed in Brazil. A …

Purpose: Li-Fraumeni syndrome (LFS), a multiorgan cancer predisposition caused by
germline TP53 mutations, confers significant cancer risks for young people (15–39 years) …

Li-Fraumeni syndrome is a rare cancer predisposition syndrome classically associated with
remarkably early onset of cancer in families with a typical spectrum of malignancies …

Abstract Li Fraumeni Syndrome (LFS) is a hereditary cancer syndrome characterized by a
high risk of developing various types of cancer from birth through late adulthood. Clinical …

Li-Fraumeni syndrome is a hereditary cancer syndrome that results in a dramatically
increased risk of developing cancer over a patient's lifetime. Proper understanding of this …

Abstract Background: Li-Fraumeni syndrome is a dominantly inherited disorder
characterized by early-onset breast cancer, sarcomas, and other cancers in children and …