Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production with high butyrate/acetate ratio

Y Suo, M Ren, X Yang, Z Liao, H Fu, J Wang - Applied microbiology and …, 2018 - Springer
Butyric acid fermentation by Clostridium couples with the synthesis of acetic acid. But the
presence of acetic acid reduces butyric acid yield and increases separation and purification …

Enhanced butyric acid production in Clostridium tyrobutyricum by overexpression of rate-limiting enzymes in the Embden-Meyerhof-Parnas pathway

Y Suo, H Fu, M Ren, Z Liao, Y Ma, J Wang - Journal of biotechnology, 2018 - Elsevier
Clostridium tyrobutyricum is an excellent microorganism for bio-based butyric acid
production. However, the main obstacles for its industrialization are low butyric acid …

Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from undetoxified corncob acid hydrolysate

Y Suo, Z Liao, C Qu, H Fu, J Wang - Bioresource technology, 2019 - Elsevier
Resistance to furan derivatives and phenolic compounds plays an important role in the use
of lignocellulosic biomass for biological production of chemicals and fuels. This study …

Metabolic engineering of Clostridium acetobutylicum for enhanced production of butyric acid

YS Jang, HM Woo, JA Im, IH Kim, SY Lee - Applied microbiology and …, 2013 - Springer
Clostridium acetobutylicum has been considered as an attractive platform host for
biorefinery due to its metabolic diversity. Considering its capability to overproduce butanol …

Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose

H Fu, L Yu, M Lin, J Wang, Z Xiu, ST Yang - Metabolic Engineering, 2017 - Elsevier
Clostridium tyrobutyricum is a promising microorganism for butyric acid production.
However, its ability to utilize xylose, the second most abundant sugar found in lignocellulosic …

Metabolic engineering of Clostridium acetobutylicum for butyric acid production with high butyric acid selectivity

YS Jang, JA Im, SY Choi, J Im Lee, SY Lee - Metabolic engineering, 2014 - Elsevier
A typical characteristic of the butyric acid-producing Clostridium is coproduction of both
butyric and acetic acids. Increasing the butyric acid selectivity important for economical …

Butyric acid and hydrogen production by Clostridium tyrobutyricum ATCC 25755 and mutants

X Liu, Y Zhu, ST Yang - Enzyme and Microbial Technology, 2006 - Elsevier
Clostridium tyrobutyricum produces butyric acid, acetic acid, hydrogen and carbon dioxide
as its main fermentation products. In this work, mutants with inactivated pta gene, encoding …

Metabolic engineering of Clostridium acetobutylicum for the production of butyl butyrate

HJ Noh, JE Woo, SY Lee, YS Jang - Applied microbiology and …, 2018 - Springer
Butyl butyrate is widely used as a fragrance additive for foods and beverages. The first step
in the currently used process is the production of precursors, including butanol and butyrate …

A non-solventogenic Clostridium beijerinckii strain lacking acetoacetate decarboxylase assimilates acetate and accumulates butyrate

J Bortolucci, ACB Zani, PF de Gouvêa… - Biomass and …, 2023 - Elsevier
Clostridium beijerinckii is a remarkable biocatalyst that can perform Acetone-Butanol-
Ethanol (ABE) fermentation. Nevertheless, some C. beijerinckii strains lose the capacity to …

Recent advances in n-butanol and butyrate production using engineered Clostridium tyrobutyricum

T Bao, J Feng, W Jiang, H Fu, J Wang… - World Journal of …, 2020 - Springer
Acidogenic clostridia naturally producing acetic and butyric acids has attracted high interest
as a novel host for butyrate and n-butanol production. Among them, Clostridium …