To kill a microglia: a case for CSF1R inhibitors

KN Green, JD Crapser, LA Hohsfield - Trends in immunology, 2020 - cell.com
Microglia, the brain's immune sentinels, have garnered much attention in recent years.
Researchers have begun to identify the manifold roles that these cells play in the central …

Present and future of microglial pharmacology

E Šimončičová, EG de Andrade, HA Vecchiarelli… - Trends in …, 2022 - cell.com
Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …

[HTML][HTML] The colony stimulating factor-1 receptor (CSF-1R)-mediated regulation of microglia/macrophages as a target for neurological disorders (Glioma, stroke)

C Barca, C Foray, S Hermann, U Herrlinger… - Frontiers in …, 2021 - frontiersin.org
Immunomodulatory therapies have fueled interest in targeting microglial cells as part of the
innate immune response after infection or injury. In this context, the colony-stimulating factor …

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

JC Nissen, KK Thompson, BL West, SE Tsirka - Experimental Neurology, 2018 - Elsevier
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS) characterized by progressive neuronal demyelination and degeneration. Much of this …

[HTML][HTML] Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation

MRP Elmore, RJ Lee, BL West, KN Green - PloS one, 2015 - journals.plos.org
Microglia are the primary immune cell in the brain and are postulated to play important roles
outside of immunity. Administration of the dual colony-stimulating factor 1 receptor …

Microglial repopulation resolves inflammation and promotes brain recovery after injury

RA Rice, J Pham, RJ Lee, AR Najafi, BL West… - Glia, 2017 - Wiley Online Library
Microglia mediate chronic neuroinflammation following central nervous system (CNS)
disease or injury, and in doing so, damage the local brain environment by impairing …

[HTML][HTML] CSF1R stimulation promotes increased neuroprotection by CD11c+ microglia in EAE

A Wlodarczyk, A Benmamar-Badel, O Cédile… - Frontiers in cellular …, 2019 - frontiersin.org
Microglia are resident immune cells of the central nervous system. Their development and
maintenance depend on stimulation of Colony Stimulating Factor-1 receptor (CSF1R) …

A limited capacity for microglial repopulation in the adult brain

AR Najafi, J Crapser, S Jiang, W Ng, A Mortazavi… - Glia, 2018 - Wiley Online Library
Microglia are the resident immune cell of the central nervous system (CNS), and serve to
protect and maintain the local brain environment. Microglia are critically dependent on …

Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders

J Han, K Zhu, XM Zhang, RA Harris - Glia, 2019 - Wiley Online Library
Microglia are prominent immune cells in the central nervous system (CNS) and are critical
players in both neurological development and homeostasis, and in neurological diseases …

[HTML][HTML] CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain

MRP Elmore, AR Najafi, MA Koike, NN Dagher… - Neuron, 2014 - ncbi.nlm.nih.gov
The colony stimulating factor 1 receptor (CSF1R) is a key regulator of myeloid lineage cells.
Genetic loss of the CSF1R blocks the normal population of resident microgliain the brain that …