To kill a microglia: a case for CSF1R inhibitors
Microglia, the brain's immune sentinels, have garnered much attention in recent years.
Researchers have begun to identify the manifold roles that these cells play in the central …
Researchers have begun to identify the manifold roles that these cells play in the central …
Present and future of microglial pharmacology
Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …
central nervous system. Mechanistically implicated in numerous neurological pathologies …
[HTML][HTML] The colony stimulating factor-1 receptor (CSF-1R)-mediated regulation of microglia/macrophages as a target for neurological disorders (Glioma, stroke)
Immunomodulatory therapies have fueled interest in targeting microglial cells as part of the
innate immune response after infection or injury. In this context, the colony-stimulating factor …
innate immune response after infection or injury. In this context, the colony-stimulating factor …
Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS) characterized by progressive neuronal demyelination and degeneration. Much of this …
(CNS) characterized by progressive neuronal demyelination and degeneration. Much of this …
[HTML][HTML] Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation
MRP Elmore, RJ Lee, BL West, KN Green - PloS one, 2015 - journals.plos.org
Microglia are the primary immune cell in the brain and are postulated to play important roles
outside of immunity. Administration of the dual colony-stimulating factor 1 receptor …
outside of immunity. Administration of the dual colony-stimulating factor 1 receptor …
Microglial repopulation resolves inflammation and promotes brain recovery after injury
RA Rice, J Pham, RJ Lee, AR Najafi, BL West… - Glia, 2017 - Wiley Online Library
Microglia mediate chronic neuroinflammation following central nervous system (CNS)
disease or injury, and in doing so, damage the local brain environment by impairing …
disease or injury, and in doing so, damage the local brain environment by impairing …
[HTML][HTML] CSF1R stimulation promotes increased neuroprotection by CD11c+ microglia in EAE
A Wlodarczyk, A Benmamar-Badel, O Cédile… - Frontiers in cellular …, 2019 - frontiersin.org
Microglia are resident immune cells of the central nervous system. Their development and
maintenance depend on stimulation of Colony Stimulating Factor-1 receptor (CSF1R) …
maintenance depend on stimulation of Colony Stimulating Factor-1 receptor (CSF1R) …
A limited capacity for microglial repopulation in the adult brain
Microglia are the resident immune cell of the central nervous system (CNS), and serve to
protect and maintain the local brain environment. Microglia are critically dependent on …
protect and maintain the local brain environment. Microglia are critically dependent on …
Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders
Microglia are prominent immune cells in the central nervous system (CNS) and are critical
players in both neurological development and homeostasis, and in neurological diseases …
players in both neurological development and homeostasis, and in neurological diseases …
[HTML][HTML] CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain
MRP Elmore, AR Najafi, MA Koike, NN Dagher… - Neuron, 2014 - ncbi.nlm.nih.gov
The colony stimulating factor 1 receptor (CSF1R) is a key regulator of myeloid lineage cells.
Genetic loss of the CSF1R blocks the normal population of resident microgliain the brain that …
Genetic loss of the CSF1R blocks the normal population of resident microgliain the brain that …