The past two years have seen significant advances in our understanding of IL-2 gene
transcription. Many of the relevant transcription factors have been identified, the intracellular …

Abstract Interleukin 1α (IL-1α) and β (IL-1β) are proinflammatory cytokines that are encoded
by distinct genes, but share most biological activities. During the past several years, intense …

Activation of T helper cell 1 (Th1) and Th2 results in transcription of the interleukin 2 (IL-2)
and IL-4 cytokine genes, respectively. Whereas many of the regulatory elements and factors …

The secretion of the T cell growth factor Interleukin 2 (IL-2) is a key event in the activation of
T lymphocytes. IL-2 triggers peripheral T lymphocytes to enter the S phase of the cell cycle …

Interleukin-2 (IL-2) transcription is developmentally restricted to T cells and physiologically
dependent on specific stimuli such as antigen recognition. Prior studies have shown that this …

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Abstract Interleukin-6 (IL-6) is a prototypical cytokine with functional pleiotropy and plays an
important role in host defense. When infections or tissue injuries occur, IL-6 is promptly …

Interleukin-4 is an immunomodulatory cytokine which plays a central role in the regulation of
allergic and atopic immune responses. Significant progress has been made in gaining a …

Interleukin 3 (IL-3 or multi-colony-stimulating factor) plays an important role in the
hematopoietic response to inflammatory stimuli through its action on both immature and …

To isolate transcription factors important in the regulation of the human interleukin-3 (IL-3)
gene, we screened a λgt11 cDNA library, constructed from phytohemagglutinin-stimulated …