The current use of animals to test for potential teratogenic effects of drugs and other
chemicals dates back to the thalidomide disaster of the late 1950s and early 1960s …

The beginnings of mammalian experimental teratology in this century are briefly reviewed
and it is noted that prior to 1960 a degree of sophistication in concept and technology had …

1. At several points, the Commission established as a criterion for permissible research an
acceptable level of risk-eg," no risk" or" minimal risk." I support the Commission's …

Despite Dr. Brent's statement earlier that animal models are not good for teratologic testing,
they are all that we have at the moment. It is not reasonable to use new compounds without …

Teratogenic testing as we know it today has only come into being since the thalidomide
tragedy of 1961. It was already well known at that time that certain chemical compounds …

The study by Brent, published 50 years ago, gives us clues and insight that even when
animal models are used to test drugs, a level of vigilance must remain for new drugs. It is a …

February-March, 1972 61 rF HE establishment of drug testing protocols for teratogenic
screening resulted primarily from the thalidomide episode. Although many laboratories …

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