Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS) characterized by progressive neuronal demyelination and degeneration. Much of this …

Microglia serve as the innate immune cells of the central nervous system (CNS) by providing
continuous surveillance of the CNS microenvironment and initiating defense mechanisms to …

Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous
system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they …

In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both
resident microglia and infiltrating macrophages contribute to demyelination as well as …

Microglia are resident immune cells of the central nervous system. Their development and
maintenance depend on stimulation of Colony Stimulating Factor-1 receptor (CSF1R) …

Microglia, the brain's immune sentinels, have garnered much attention in recent years.
Researchers have begun to identify the manifold roles that these cells play in the central …

Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous
system (CNS). Despite introducing multiple immunomodulatory approaches for MS, there …

Immunomodulatory therapies have fueled interest in targeting microglial cells as part of the
innate immune response after infection or injury. In this context, the colony-stimulating factor …

Secondary progressive multiple sclerosis (SPMS) is an autoimmune disease of the central
nervous system (CNS) characterized by progressive motor dysfunction, sensory deficits, and …

A pathological hallmark of multiple sclerosis (MS) is myelin loss in brain white matter
accompanied by compromised remyelination. Demyelinated lesions are deeply associated …