Epithelial-cadherin (E-cadherin) is a master organizer of the epithelial phenotype. Its
function is regulated in part by p120-catenin (referred to herein as p120), a cytoplasmic …

The intestinal epithelium is characterized by rapid cellular turnover with continuous
proliferation of multipotential stem cells within Lieberkuhn's crypts, cellular migration along …

The epithelial monolayer of the intestine is a selective barrier permitting nutrient and
electrolyte absorption yet acting to protect the underlying tissue compartments and cellular …

The E-cadherin–catenin complex is important for the maintenance of epithelial architecture.
We studied its expression in Crohn disease, ulcerative colitis, acute ileitis, and controls …

p120 loss destabilizes E-cadherin and could therefore result in tumor and/or metastasis-
promoting activities similar to those caused by E-cadherin downregulation. Previously, we …

Background E-cadherin is a major component of adherens junctions. Impaired expression of
E-cadherin in the small intestine and colon has been linked to a disturbed intestinal …

The intestinal epithelial layer forms an important barrier that protects underlying tissues from
bacteria within the gut lumen. This single monolayer is comprised of epithelial cells that are …

Îndirect evidence suggests that p120-catenin (p120) can both positively and negatively
affect cadherin adhesiveness. Here we show that the p120 gene is mutated in SW48 cells …

We conditionally substituted E-cadherin (E-cad; cadherin 1) with N-cadherin (N-cad;
cadherin 2) during intestine development by generating mice in which an Ncad cDNA was …

p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism
has not been established. Here, we show that p120 acts at the cell surface to control …