Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T
cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we …

Aims/hypothesis We aimed to characterise and quantify the expression of HLA class II (HLA-
II) in human pancreatic tissue sections and to analyse its induction in human islets. Methods …

Type 1 diabetes results from the autoimmune destruction of insulin-producing pancreatic β-
cells by cytotoxic T-lymphocytes (CTLs). In humans, few β-cell epitopes have been reported …

Type 1 diabetes (T1D) develops when insulin-secreting β-cells, found in the pancreatic islets
of Langerhans, are destroyed by infiltrating T cells. How human T cells recognize β-cell …

Selective expression of the human class Ib HLA molecule HLA-G in immunologically
protected sites and its function in the inhibition of NK and T-cell effector functions support an …

Aims/hypothesis Human pancreatic beta cells may be complicit in their own demise in type 1
diabetes, but how this occurs remains unclear. One potentially contributing factor is …

Previous cross-sectional analyses demonstrated that CD8+ and CD4+ T-cell reactivity to
islet-specific antigens was more prevalent in T1D subjects than in healthy donors (HD) …

Type 1 diabetes results from destruction of pancreatic beta cells by autoreactive T cells. Both
CD4+ and CD8+ T cells have been shown to mediate beta‐cell killing. While CD8+ T cells …

Type 1 diabetes (T1D) results from T cell–mediated destruction of insulin-producing β-cells.
Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified …

OBJECTIVE—CD8+ T-cells specific for islet antigens are essential for the development of
type 1 diabetes in the NOD mouse model of the disease. Such T-cells can also be detected …