Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure: Refining the Gut Hypothesis

WHW Tang, Z Wang, Y Fan, B Levison… - Journal of the American …, 2014 - jacc.org
Background: Altered intestinal function is prevalent in patients with heart failure (HF), but its
role in adverse outcomes is unclear. Objectives: This study investigated the potential …

Microbiota‐dependent metabolite trimethylamine‐N‐oxide is associated with disease severity and survival of patients with chronic heart failure

M Trøseid, T Ueland, JR Hov, A Svardal… - Journal of internal …, 2015 - Wiley Online Library
Objectives Recent metabolomic, experimental and clinical studies have demonstrated that
trimethylamine‐N‐oxide (TMAO), a microbiota‐dependent metabolite from dietary …

Gut microbiota‐derived trimethylamine N‐oxide is associated with poor prognosis in patients with heart failure

W Li, A Huang, H Zhu, X Liu, X Huang… - Medical Journal of …, 2020 - Wiley Online Library
Objective Gut microbiota‐produced trimethylamine N‐oxide (TMAO) is a risk factor for
cardiovascular events. However, conflicting findings regarding the link between plasma …

Trimethylamine N‐oxide and cardiovascular outcomes in patients with chronic heart failure after myocardial infarction

X Zhou, M Jin, L Liu, Z Yu, X Lu, H Zhang - ESC heart failure, 2020 - Wiley Online Library
Aim Accumulating evidence has demonstrated that intestinal microbiota‐dependent
trimethylamine N‐oxide (TMAO) is involved in the pathogenesis of various cardiovascular …

The heart and gut relationship: a systematic review of the evaluation of the microbiome and trimethylamine-N-oxide (TMAO) in heart failure

KM Anderson, EP Ferranti, EC Alagha… - Heart Failure …, 2022 - Springer
There is an expanding body of research on the bidirectional relationship of the human gut
microbiome and cardiovascular disease, including heart failure (HF). Researchers are …

Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure

WHW Tang, Z Wang, K Shrestha, AG Borowski… - Journal of cardiac …, 2015 - Elsevier
Abstract Background Trimethylamine-N-oxide (TMAO) has been linked to increased
cardiovascular risk. We aimed to determine the prognostic value of TMAO and its dietary …

[HTML][HTML] TMAO: how gut microbiota contributes to heart failure

Y Zhang, Y Wang, B Ke, J Du - Translational Research, 2021 - Elsevier
An increasing amount of evidence reveals that the gut microbiota is involved in the
pathogenesis and progression of various cardiovascular diseases. In patients with heart …

Association with outcomes and response to treatment of trimethylamine N‐oxide in heart failure: results from BIOSTAT‐CHF

T Suzuki, Y Yazaki, AA Voors… - European journal of …, 2019 - Wiley Online Library
Aims Association of elevated circulating levels of trimethylamine N‐oxide (TMAO) with
adverse outcomes in patients with heart failure (HF) has been described. However …

Trimethylamine N-oxide and prognosis in acute heart failure

T Suzuki, LM Heaney, SS Bhandari, DJL Jones, LL Ng - Heart, 2016 - heart.bmj.com
Objective Acute heart failure (AHF) is associated with high mortality and morbidity.
Trimethylamine N-oxide (TMAO), a gut-derived metabolite, has reported association with …

Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

WHW Tang, Z Wang, XS Li, Y Fan, DS Li, Y Wu… - Clinical …, 2017 - academic.oup.com
BACKGROUND Recent studies show a mechanistic link between intestinal microbial
metabolism of dietary phosphatidylcholine and coronary artery disease pathogenesis …