Clinical and experimental evidence indicates that intestinal inflammatory conditions can be
exacerbated by behavioral conditions such as depression. The recent demonstration of a …

Background & Aims: Psychiatric factors may determine gastrointestinal health outcomes.
Here, we used a model of depression based on neonatal maternal separation (MS) to …

BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) frequently also
have depression, yet little is known of its role in IBD pathogenesis. We investigated whether …

Background & Aims: The recently proposed Inflammatory Reflex describes an interaction
between the vagus nerve and peripheral macrophages, resulting in attenuation of …

It is common knowledge that dysfunction of the immune and neuroendocrine systems, in
addition to neuroplasticity, is among the pathways that underlie irritable bowel syndrome …

This review examines preclinical and clinical studies relevant to our understanding of how
the bidirectional gut-brain axis influences the natural history of inflammatory bowel disease …

BACKGROUND & AIMS:: Clinical and preclinical studies have associated gastrointestinal
inflammation and infection with altered behavior. We investigated whether chronic gut …

Depression and anxiety are common comorbid disorders observed in patients with
inflammatory bowel disease (IBD). Increasing line of evidence indicates that immune …

Psychological stress has long been reported anecdotally to increase disease activity in
inflammatory bowel disease (IBD), and recent well designed studies have confirmed that …

The vagus nerve inhibits the response to systemic administration of endotoxin, and we have
recently extended this observation to show that the vagus attenuates acute experimental …