The blood vessel system is essential for skin homeostasis and regeneration. While the
heterogeneity of vascular endothelial cells has been emergingly revealed, whether a …

Background: Insufficient blood supply results in unsatisfactory wound healing, especially for
challenging wound repair such as diabetic wound defects. Regular exercise training brings …

Stem cell extracellular vesicles (EVs) have been widely studied because of their excellent
therapeutic potential. EVs from different types of stem cell can improve vascularization as …

Background A refractory wound is a typical complication of diabetes and is a common
outcome after surgery. Current approaches have difficulty in improving wound healing …

Extracellular vesicles (EVs) derived from mesenchymal stem cells isolated from both bone
marrow (BMSCs) and adipose tissue (ADSCs) show potential therapeutic effects. These …

Endothelial dysfunction caused by persistent hyperglycemia in diabetes is responsible for
impaired angiogenesis in diabetic wounds. Extracellular vehicles (EVs) are considered …

Background: Impaired potential of hypoxia-mediated angiogenesis lead poor healing of
diabetic wounds. Previous studies have shown that extracellular vesicles from adipose …

Tissue regeneration is often impaired in patients with metabolic disorders such as diabetes
mellitus and obesity, exhibiting reduced wound repair and limited regeneration capacity. We …

Introduction Extracellular vesicles from mesenchymal stromal cells (MSC-EVs) have shown
promise in wound healing. Their use in diabetic wounds specifically, however, remains pre …

Background Persistent hyperglycaemia in diabetes causes functional abnormalities of
human dermal fibroblasts (HDFs), partially leading to delayed skin wound healing …