Since its approval in 1979 cisplatin has become an important component in chemotherapy
regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as …

Platinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of
human neoplasms. Their clinical success is, however, limited due to severe side effects and …

The discovery of cis-platin and its second and third generation analogues created a hope in
cancer chemotherapy. Cis-platin and its second generation analogue carboplatin have been …

Cisplatin was one of the first chemotherapeutic agents to exhibit broad efficacy in solid
tumors and it remains among the most widely used agents in the treatment of cancer. Its …

The discovery of cis-platin was serendipitous. In 1965, Rosenberg was looking into the
effects of an electric field on the growth of Escherichia coli bacteria. He noticed that bacteria …

The history of platinum in cancer treatment began 150 years ago with the first synthesis of
cisplatin; but it was not used in the clinic before 30 years ago. Then 3000 derivatives were …

The platinum agents (cisplatin, carboplatin and oxaliplatin) are among the most useful
anticancer agents available to oncologists. The drugs have the potential to produce both …

It all started with an accidental discovery in the laboratory of Dr. Barnet Rosenberg at
Michigan State University in the mid 1960s. Now, thirty years from the landmark publication …

Platinum (Pt) compounds entered the clinic as anticancer agents when cisplatin was
approved in 1978. More than 40 years later, even in the era of precision medicine and …

Journal of Clinical Oncology recently featured the dramatic changes that took place within
the last 50 years resulting in transforming malignant germ cell testicular tumors from highly …