Human islets of Langerhans are complex micro-organs responsible for maintaining glucose
homeostasis. Islets contain five different endocrine cell types, which react to changes in …

The Islets of Langerhans: Biochemistry, Physiology, and Pathology reviews the state of
knowledge in the complex phenomena involved in the functioning of the multiendocrine …

While a number of structural and cellular abnormalities occur in the islet of Langerhans in
diabetes, and in particular in type 2 diabetes, the focus has been mostly on the insulin …

The islets of Langerhans, discovered by a medical student 121 years ago (1), occupy a
pivotal position in the endocrine control of fuel metabolism. In the past decade, research has …

In recent years models for the internal (“intra-islet”) regulation of hormone secretion have
been proposed to explain how different islet cells might regulate each other by means of …

We present a new technique for analyzing the three-dimensional structure of intact isolated
islets of Langerhans. Adult rat and human islets were stained with whole-mount …

Before the middle of the previous century, cell types of the pancreatic islets of Langerhans
were identified primarily on the basis of their color reactions with histological dyes. At that …

Blood glucose homeostasis requires proper function of pancreatic islets, which secrete
insulin, glucagon and somatostatin from the β-, α-and δ-cells respectively. Each islet cell …

The islet of Langerhans is a unique micro-organ within the exocrine pancreas, which is
composed of insulin-secreting beta-cells, glucagon-secreting alpha-cells, somatostatin …

The ideal way to determine the defect in insulin secretion in diabetes mellitus would be to
isolate and study the pancreatic islets of normal and diabetic subjects. Because of the great …