Today, we know that a primary metabolic action of insulin is to facilitate the postprandial
disposition of glucose via its actions on three key target tissues: suppression of glucose …

The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …

Ever since the discovery of insulin and its role in the regulation of glucose uptake and
utilization, there has been great interest in insulin, its structure and the way in which it …

Throughout much of the last century insulin served a central role in the advancement of
peptide chemistry, pharmacology, cell signaling and structural biology. These discoveries …

Diabetes mellitus is a major and growing public health problem throughout the world, with
an estimated worldwide prevalence in 2000 of 150 million people, expected to increase to …

One day, in a moment of weakness, I fell prey to the temptation to organize and edit this
volume on the mechanism of insulin action. The major reason for attempting to resist, of …

Following the discovery of insulin, it took the rest of the twentieth century to understand how
this hormone regulates intracellular metabolism. What are the main discoveries that led to …

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes: Cell Skip
to Main Content Advertisement Cell This journal offers authors two options (open access or …

The pathological sequence for type 2 diabetes is complex and entails many different
elements that act in concert to cause that disease. This review proposes a sequence of …

2021 to 2022 marks the one hundredth anniversary of ground-breaking research in Toronto
that changed the course of what was, then, a universally fatal disease: type 1 diabetes …