Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …

An extraordinary series of discoveries about chronic myeloid leukemia (CML) has made this
disease a model of the way in which bench and bedside research can unite and culminate …

In the past decade clinical and laboratory studies have led to important new insights into the
biology of chronic myeloid leukemia (CML). Basic science has defined the molecular …

Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning
with the first discovery of leukemia and the description of the Philadelphia Chromosome and …

The chronological history of the important discoveries leading to our present understanding
of the essential clinical, biological, biochemical, and molecular features of chronic …

Chronic myeloid leukemia (CML) is the prototype cytogenetic malignancy. Even before the
development of basic G-and R-banding techniques, CML was found to be associated with a …

In less than 10 years, the prognosis of chronic myeloid leukaemia has changed from that of
a fatal disease to a disorder amenable simply to lifelong oral medication and compatible …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed,
primitive hematopoietic progenitor cells. It involves myeloid, monocytic, erythroid …

In the last decade, improvements in both non-transplant and transplant therapy have
extended the lives of patients with CML, particularly those in chronic phase. The future will …

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease with distinct biological
and clinical features. The biologic basis of the stereotypical progression from chronic phase …