Controversies on acetylcholine-induced increases or decreases in coronary blood flow arise
from obvious species differences, the role of endothelium in mediating vascular smooth …

Controversies on acetylcholine-induced increases or decreases in coronary blood flow arise
from obvious species differences, the role of endothelium in mediating vascular smooth …

The powerful local metabolic regulation adjusting coronary blood flow to myocardial oxygen
consumption under normal conditions is beyond doubt. However, despite substantial …

In animals, acetylcholine dilates normal arteries and produces vasoconstriction in the
presence of hypercholesterolemia, hypertension, or atherosclerosis, reflecting endothelial …

Parasympathetic control of coronary blood flow has been extensively studied in dogs, and a
clear vasodilator effect not dependent on changes in myocardial metabolism was observed …

Intracoronary administration of acetylcholine or efferent vagal stimulation causes coronary
vasodilation in dogs. However, in baboons it has been reported that intracoronary …

In animal experiments, acetylcholine is generally a vasodilator acting indirectly by releasing
endothelium‐derived relaxing factor (EDRF); for example, in dog and rabbit small coronaries …

An endothelium-dependent vasodilator response to acetylcholine has been described
recently in patients with coronary artery disease. Those studies determined responses only …

Acetylcholine acts on the different components of the coronary arterial wall by 1) initiating
endothelium-dependent relaxation of the smooth muscle cells; 2) inhibiting the exocytotic …

Objectives: In vivo studies of the human coronary resistance circulation cannot control for
indirect effects of myocardial metabolism, compression, and neurohumoral influences. This …