Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

Abstract Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss
of hypocretin/orexin signaling in the brain. Genetic, epidemiological and experimental data …

Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association
with the HLA DQB1* 06: 02/DQA1* 01: 02 (98% vs. 25%) heterodimer (DQ0602), T cell …

Narcolepsy, a disorder strongly associated with human leukocyte antigen (HLA)–DQA1* 01:
02/DQB1* 06: 02 (DQ0602), is characterized by excessive daytime sleepiness, cataplexy …

The loss of hypothalamic hypocretin/orexin (hcrt) producing neurons causes narcolepsy with
cataplexy. An autoimmune basis for the disease has long been suspected and recent results …

Highlights•Narcolepsy is caused by the loss of hypocretin-producing neurons in the
brain.•HLA DQB1* 06: 02 association suggests an autoimmune basis for narcolepsy.• …

Narcolepsy with cataplexy is a rare and severe sleep disorder caused by the destruction of
orexinergic neurons in the lateral hypothalamus. The genetic and environmental factors …

Recent advances in the identification of susceptibility genes and environmental exposures
provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin …

In recent years, a growing number of potential autoimmune disorders affecting neurons in
the central nervous system have been identified, including narcolepsy. Narcolepsy is a …

Human narcolepsy with cataplexy is a neurological disorder, which develops due to a
deficiency in hypocretin producing neurons in the hypothalamus. There is a strong …