The combination of mesoglycan and VEGF promotes skin wound repair by enhancing the activation of endothelial cells and fibroblasts and their cross-talk

R Belvedere, N Novizio, S Morello, A Petrella - Scientific reports, 2022 - nature.com
Skin wound healing requires accurate therapeutic topical managements to accelerate tissue
regeneration. Here, for the first time, we found that the association mesoglycan/VEGF has a …

Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound …

R Belvedere, E Pessolano, A Porta, A Tosco… - European journal of …, 2020 - Elsevier
Mesoglycan is a fibrinolytic compound but recently promising pro-healing effects in skin
wound repair have been reported. Previously, we have showed that mesoglycan activates …

The Pharmaceutical Device Prisma® Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing

R Belvedere, V Bizzarro, L Parente, F Petrella… - International Journal of …, 2017 - mdpi.com
Glycosaminoglycans are polysaccharides of the extracellular matrix supporting skin wound
closure. Mesoglycan is a mixture of glycosaminoglycans such as chondroitin-, dermatan …

Mesoglycan induces keratinocyte activation by triggering syndecan‐4 pathway and the formation of the annexin A1/S100A11 complex

V Bizzarro, R Belvedere, E Pessolano… - Journal of Cellular …, 2019 - Wiley Online Library
Wound healing is a dynamic process comprising multiple events, such as inflammation, re‐
epithelialization, and tissue remodeling. Re‐epithelialization phase is characterized by the …

Novel non-angiogenic role for mesenchymal stem cell-derived vascular endothelial growth factor on keratinocytes during wound healing

HT Ong, RJ Dilley - Cytokine & growth factor reviews, 2018 - Elsevier
With chronic wounds remaining a substantial healthcare issue, new therapies are sought to
improve patient outcomes. Various studies have explored the benefits of promoting …

Roles of proteoglycans and glycosaminoglycans in wound healing and fibrosis

S Ghatak, EV Maytin, JA Mack… - … journal of cell …, 2015 - Wiley Online Library
A wound is a type of injury that damages living tissues. In this review, we will be referring
mainly to healing responses in the organs including skin and the lungs. Fibrosis is a process …

Small leucine-rich proteoglycans in skin wound healing

X Pang, N Dong, Z Zheng - Frontiers in Pharmacology, 2020 - frontiersin.org
Healing of cutaneous wounds is a complex and well-coordinated process requiring
cooperation among multiple cells from different lineages and delicately orchestrated …

Vascular endothelial growth factor-recruiting nanofiber bandages promote multifunctional skin regeneration via improved angiogenesis and immunomodulation

Y Chen, Z Yuan, W Sun, M Shafiq, J Zhu, J Chen… - Advanced Fiber …, 2023 - Springer
Tissue injury leads to gradients of chemoattractants, which drive multiple processes for
tissue repair, including the inflammatory response as well as endogenous cell recruitment …

Lentinan-loaded GelMA hydrogel accelerates diabetic wound healing through enhanced angiogenesis and immune microenvironment modulation

Z Jia, L Chen, D Gu, X Li, T Wen, W Li - International Journal of Biological …, 2024 - Elsevier
Diabetic wound healing is a substantial clinical challenge, characterized by delayed
angiogenesis and unresolved inflammation. Lentinan, a polysaccharide extracted from …

Gellan gum-hyaluronic acid spongy-like hydrogels and cells from adipose tissue synergize promoting neoskin vascularization

MT Cerqueira, LP da Silva, TC Santos… - … applied materials & …, 2014 - ACS Publications
Currently available substitutes for skin wound healing often result in the formation of
nonfunctional neotissue. Thus, urgent care is still needed to promote an effective and …