The combination of mesoglycan and VEGF promotes skin wound repair by enhancing the activation of endothelial cells and fibroblasts and their cross-talk
R Belvedere, N Novizio, S Morello, A Petrella - Scientific reports, 2022 - nature.com
Skin wound healing requires accurate therapeutic topical managements to accelerate tissue
regeneration. Here, for the first time, we found that the association mesoglycan/VEGF has a …
regeneration. Here, for the first time, we found that the association mesoglycan/VEGF has a …
Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound …
R Belvedere, E Pessolano, A Porta, A Tosco… - European journal of …, 2020 - Elsevier
Mesoglycan is a fibrinolytic compound but recently promising pro-healing effects in skin
wound repair have been reported. Previously, we have showed that mesoglycan activates …
wound repair have been reported. Previously, we have showed that mesoglycan activates …
The Pharmaceutical Device Prisma® Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing
R Belvedere, V Bizzarro, L Parente, F Petrella… - International Journal of …, 2017 - mdpi.com
Glycosaminoglycans are polysaccharides of the extracellular matrix supporting skin wound
closure. Mesoglycan is a mixture of glycosaminoglycans such as chondroitin-, dermatan …
closure. Mesoglycan is a mixture of glycosaminoglycans such as chondroitin-, dermatan …
Mesoglycan induces keratinocyte activation by triggering syndecan‐4 pathway and the formation of the annexin A1/S100A11 complex
V Bizzarro, R Belvedere, E Pessolano… - Journal of Cellular …, 2019 - Wiley Online Library
Wound healing is a dynamic process comprising multiple events, such as inflammation, re‐
epithelialization, and tissue remodeling. Re‐epithelialization phase is characterized by the …
epithelialization, and tissue remodeling. Re‐epithelialization phase is characterized by the …
Novel non-angiogenic role for mesenchymal stem cell-derived vascular endothelial growth factor on keratinocytes during wound healing
With chronic wounds remaining a substantial healthcare issue, new therapies are sought to
improve patient outcomes. Various studies have explored the benefits of promoting …
improve patient outcomes. Various studies have explored the benefits of promoting …
Roles of proteoglycans and glycosaminoglycans in wound healing and fibrosis
S Ghatak, EV Maytin, JA Mack… - … journal of cell …, 2015 - Wiley Online Library
A wound is a type of injury that damages living tissues. In this review, we will be referring
mainly to healing responses in the organs including skin and the lungs. Fibrosis is a process …
mainly to healing responses in the organs including skin and the lungs. Fibrosis is a process …
Small leucine-rich proteoglycans in skin wound healing
X Pang, N Dong, Z Zheng - Frontiers in Pharmacology, 2020 - frontiersin.org
Healing of cutaneous wounds is a complex and well-coordinated process requiring
cooperation among multiple cells from different lineages and delicately orchestrated …
cooperation among multiple cells from different lineages and delicately orchestrated …
Vascular endothelial growth factor-recruiting nanofiber bandages promote multifunctional skin regeneration via improved angiogenesis and immunomodulation
Y Chen, Z Yuan, W Sun, M Shafiq, J Zhu, J Chen… - Advanced Fiber …, 2023 - Springer
Tissue injury leads to gradients of chemoattractants, which drive multiple processes for
tissue repair, including the inflammatory response as well as endogenous cell recruitment …
tissue repair, including the inflammatory response as well as endogenous cell recruitment …
Lentinan-loaded GelMA hydrogel accelerates diabetic wound healing through enhanced angiogenesis and immune microenvironment modulation
Z Jia, L Chen, D Gu, X Li, T Wen, W Li - International Journal of Biological …, 2024 - Elsevier
Diabetic wound healing is a substantial clinical challenge, characterized by delayed
angiogenesis and unresolved inflammation. Lentinan, a polysaccharide extracted from …
angiogenesis and unresolved inflammation. Lentinan, a polysaccharide extracted from …
Gellan gum-hyaluronic acid spongy-like hydrogels and cells from adipose tissue synergize promoting neoskin vascularization
Currently available substitutes for skin wound healing often result in the formation of
nonfunctional neotissue. Thus, urgent care is still needed to promote an effective and …
nonfunctional neotissue. Thus, urgent care is still needed to promote an effective and …