Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

DM Dudley, KK Van Rompay, LL Coffey, A Ardeshir… - Nature medicine, 2018 - nature.com
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here,
we found that 26% of nonhuman primates infected with Asian/American ZIKV in early …

[HTML][HTML] Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

DM Magnani, TF Rogers, NJ Maness… - Nature …, 2018 - nature.com
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of
fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a …

[HTML][HTML] Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

AJ Hirsch, VHJ Roberts, PL Grigsby, N Haese… - Nature …, 2018 - nature.com
Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth
restriction and fetal central nervous system malformations, which are outcomes broadly …

Zika viral dynamics and shedding in rhesus and cynomolgus macaques

CE Osuna, SY Lim, C Deleage, BD Griffin, D Stein… - Nature medicine, 2016 - nature.com
Infection with Zika virus has been associated with serious neurological complications and
fetal abnormalities. However, the dynamics of viral infection, replication and shedding are …

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

KM Adams Waldorf, JE Stencel-Baerenwald… - Nature medicine, 2016 - nature.com
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a
pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved …

[HTML][HTML] Experimental Zika virus infection in the pregnant common marmoset induces spontaneous fetal loss and neurodevelopmental abnormalities

M Seferovic, C Sánchez-San Martín, SD Tardif… - Scientific reports, 2018 - nature.com
During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly
shown to cause fetal loss and congenital malformations in acutely and chronically infected …

[HTML][HTML] Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques

SM Nguyen, KM Antony, DM Dudley, S Kohn… - PLoS …, 2017 - journals.plos.org
Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To
model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV …

[HTML][HTML] A rhesus macaque model of Asian-lineage Zika virus infection

DM Dudley, MT Aliota, EL Mohr, AM Weiler… - Nature …, 2016 - nature.com
Abstract Infection with Asian-lineage Zika virus (ZIKV) has been associated with Guillain–
Barré syndrome and fetal abnormalities, but the underlying mechanisms remain poorly …

[HTML][HTML] Zika virus infection during pregnancy in mice causes placental damage and fetal demise

JJ Miner, B Cao, J Govero, AM Smith, E Fernandez… - Cell, 2016 - cell.com
Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction,
spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental …

[HTML][HTML] Fetal neuropathology in Zika virus-infected pregnant female rhesus monkeys

AJ Martinot, P Abbink, O Afacan, AK Prohl, R Bronson… - Cell, 2018 - cell.com
The development of interventions to prevent congenital Zika syndrome (CZS) has been
limited by the lack of an established nonhuman primate model. Here we show that infection …