One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

AKT is a serine/threonine protein kinase, also known as protein kinase B, which regulates
cardiac growth, myocardial angiogenesis, glucose metabolism, and cell death in cardiac …

Akt is an important signaling molecule that modulates many cellular processes such as cell
growth, survival, and metabolism. Akt activation has been proposed as a potential strategy …

Background The serine-threonine kinase Akt is activated by several ligand-receptor systems
previously shown to be cardioprotective. Akt activation reduces cardiomyocyte apoptosis in …

The Akt family of serine-threonine kinases participates in diverse cellular processes,
including the promotion of cell survival, glucose metabolism, and cellular protein synthesis …

Akt activation reduces cardiomyocyte death and induces cardiac hypertrophy. To help
identify effector mechanisms, gene expression profiles in hearts from transgenic mice with …

The serine-threonine kinase, Akt, inhibits cardiomyocyte apoptosis acutely both in vitro and
in vivo. However, the effects of chronic Akt activation in the heart are unknown. To address …

Physiological cardiac growth is a feature of normal postnatal development in which an
increase in cardiac muscle cell diameter is observed as infants mature to adults. 1 This …

The serine-threonine kinase Akt seems to be central in mediating stimuli from different
classes of receptors. In fact, both IGF-1 and IL6-like cytokines induce hypertrophic and …

Postnatal growth of the heart is primarily achieved through hypertrophy of individual
myocytes. Cardiac growth observed in athletes represents adaptive or physiological …