Desmosomal cadherins in health and disease

M Hegazy, AL Perl, SA Svoboda… - Annual Review of …, 2022 - annualreviews.org
Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion

RL Dusek, LM Godsel, KJ Green - Journal of dermatological science, 2007 - Elsevier
The desmosomal cadherins, which include desmogleins and desmocollins, are Ca2+-
dependent adhesion molecules that cooperate to make up the adhesive core of intercellular …

Membrane-impermeable Cross-linking Provides Evidence for Homophilic, Isoform-specific Binding of Desmosomal Cadherins in Epithelial Cells*♦

Z Nie, A Merritt, M Rouhi-Parkouhi, L Tabernero… - Journal of biological …, 2011 - ASBMB
Desmosomes and adherens junctions are cadherin-based protein complexes responsible
for cell-cell adhesion of epithelial cells. Type 1 cadherins of adherens junctions show …

[HTML][HTML] Desmosomes: new perspectives on a classic

KJ Green, CL Simpson - Journal of Investigative Dermatology, 2007 - Elsevier
Desmosomes are highly specialized anchoring junctions that link intermediate filaments to
sites of intercellular adhesion, thus facilitating the formation of a supracellular scaffolding …

Structural basis of adhesive binding by desmocollins and desmogleins

OJ Harrison, J Brasch, G Lasso… - Proceedings of the …, 2016 - National Acad Sciences
Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues.
Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and …

E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion

V Rötzer, E Hartlieb, F Vielmuth, M Gliem… - Cellular and molecular …, 2015 - Springer
Desmosomes provide strong intercellular cohesion essential for the integrity of cells and
tissues exposed to continuous mechanical stress. For desmosome assembly, constitutively …

Hyper-adhesion: a new concept in cell–cell adhesion

D Garrod, TE Kimura - Biochemical Society Transactions, 2008 - portlandpress.com
We have developed a new concept of cell–cell adhesion termed 'hyper-adhesion', the very
strong adhesion adopted by desmosomes. This uniquely desmosomal property accounts for …

Structure, function, and regulation of desmosomes

AP Kowalczyk, KJ Green - Progress in molecular biology and translational …, 2013 - Elsevier
Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells
by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate …

[HTML][HTML] Genetic evidence for a novel human desmosomal cadherin, desmoglein 4

NV Whittock, C Bower - Journal of investigative dermatology, 2003 - Elsevier
Desmosomes are essential adhesion structures in most epithelia that link the intermediate
filament network of one cell to its neighbor, thereby forming a strong bond. The molecular …

Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes

OE Nekrasova, EV Amargo, WO Smith, J Chen… - Journal of Cell …, 2011 - rupress.org
The desmosomal cadherins, desmogleins (Dsgs) and desmocollins (Dscs), comprise the
adhesive core of intercellular junctions known as desmosomes. Although these adhesion …