Abstract Systems medicine is founded on a mechanism-based approach and identifies in
this way specific therapeutic targets. This approach has been applied for the transcription …

In the last decade, cognitive frailty has gained great attention from the scientific community. It
is characterized by high inflammation and oxidant state, endocrine and metabolic …

Alzheimer's disease (AD) is a common neurodegenerative disorder that affects the elderly.
One of the key features of AD is the accumulation of reactive oxygen species (ROS), which …

The increase in human life expectancy has become a challenge to reduce the deleterious
consequences of aging. Nowadays, an increasing number of the population suffer from age …

Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

The world population is aging rapidly, and increasing lifespan exacerbates the burden of
age-related health issues. On the other hand, premature aging has begun to be a problem …

Ozone, one of the most important air pollutants, is a triatomic molecule containing three
atoms of oxygen that results in an unstable form due to its mesomeric structure. It has been …

The brain shows a high sensitivity to oxidative stress (OS). Thus, the maintenance and
homeostasis of the brain, in particular neural cells, regarding the reduction-oxidation (redox) …

Activation of microglial cells and impaired mitochondrial function are common pathological
characteristics of many neurological diseases and contribute to increased generation of …

Alzheimer's disease (AD) is a multifaceted disease that is hard to treat by single-modal
treatment. AD starts with amyloid peptides, mitochondrial dysfunction, and oxidative stress …