Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Extracellular acidosis resulting from intense metabolic activities in tumors promotes cancer
cell migration, invasion, and metastasis. Although host cells die at low extracellular pH …

Summary Monocarboxylate transporter 1 (MCT1) inhibition is thought to block tumor growth
through disruption of lactate transport and glycolysis. Here, we show MCT1 inhibition …

High rate of glycolysis is a metabolic hallmark of cancer. While anaerobic glycolysis
promotes energy production under hypoxia, aerobic glycolysis, the Warburg effect, offers a …

Hypoxia and oncogene expression both stimulate glycolytic metabolism in tumors, thereby
leading to lactate production. However, lactate is more than merely a by-product of …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Monocarboxylate transporters (MCTs) constitute a family of 14 members among which
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …

High lactate concentration in tumors is associated with bad prognosis. Lactate is released by
glycolytic cells in tumors and recaptured by oxidative cancer cells to feed the tricarboxylic …

The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and
out of tumor cells. Whereas most oxidative cancer cells import lactate through MCT1 to fuel …

Monocarboxylate transporters (MCTs) represent a diverse group of transmembrane proteins
encoded by the SLC16 gene family found ubiquitously across mammalian species. Two …