[HTML][HTML] Monocarboxylate transporters in cancer
VL Payen, E Mina, VF Van Hée, PE Porporato… - Molecular …, 2020 - Elsevier
Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …
Monocarboxylate transporter MCT1 promotes tumor metastasis independently of its activity as a lactate transporter
VL Payen, MY Hsu, KS Rädecke, E Wyart, T Vazeille… - Cancer research, 2017 - AACR
Extracellular acidosis resulting from intense metabolic activities in tumors promotes cancer
cell migration, invasion, and metastasis. Although host cells die at low extracellular pH …
cell migration, invasion, and metastasis. Although host cells die at low extracellular pH …
[HTML][HTML] MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4
Summary Monocarboxylate transporter 1 (MCT1) inhibition is thought to block tumor growth
through disruption of lactate transport and glycolysis. Here, we show MCT1 inhibition …
through disruption of lactate transport and glycolysis. Here, we show MCT1 inhibition …
Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis
S Dhup, R Kumar Dadhich… - Current …, 2012 - ingentaconnect.com
High rate of glycolysis is a metabolic hallmark of cancer. While anaerobic glycolysis
promotes energy production under hypoxia, aerobic glycolysis, the Warburg effect, offers a …
promotes energy production under hypoxia, aerobic glycolysis, the Warburg effect, offers a …
Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
N Draoui, O Feron - Disease models & mechanisms, 2011 - journals.biologists.com
Hypoxia and oncogene expression both stimulate glycolytic metabolism in tumors, thereby
leading to lactate production. However, lactate is more than merely a by-product of …
leading to lactate production. However, lactate is more than merely a by-product of …
Targeting monocarboxylate transporters (MCTs) in cancer: how close are we to the clinics?
As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …
causing an excess production of lactate along with an increase in extracellular acidity …
[HTML][HTML] Monocarboxylate transporters in the brain and in cancer
J Pérez-Escuredo, VF Van Hée, M Sboarina… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Monocarboxylate transporters (MCTs) constitute a family of 14 members among which
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux
N Draoui, O Schicke, E Seront, C Bouzin… - Molecular cancer …, 2014 - AACR
High lactate concentration in tumors is associated with bad prognosis. Lactate is released by
glycolytic cells in tumors and recaptured by oxidative cancer cells to feed the tricarboxylic …
glycolytic cells in tumors and recaptured by oxidative cancer cells to feed the tricarboxylic …
Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors
The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and
out of tumor cells. Whereas most oxidative cancer cells import lactate through MCT1 to fuel …
out of tumor cells. Whereas most oxidative cancer cells import lactate through MCT1 to fuel …
[HTML][HTML] An overview of MCT1 and MCT4 in GBM: small molecule transporters with large implications
SJ Park, CP Smith, RR Wilbur, CP Cain… - American journal of …, 2018 - ncbi.nlm.nih.gov
Monocarboxylate transporters (MCTs) represent a diverse group of transmembrane proteins
encoded by the SLC16 gene family found ubiquitously across mammalian species. Two …
encoded by the SLC16 gene family found ubiquitously across mammalian species. Two …