Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory

R Hu, CLL Saw, R Yu, ANT Kong - Antioxidants & redox signaling, 2010 - liebertpub.com
Cancer chemoprevention is a process of using either natural or synthetic compounds to
reduce the risk of developing cancer. Observations that NF-E2-related factor 2 (Nrf2) …

Dual roles of Nrf2 in cancer

A Lau, NF Villeneuve, Z Sun, PK Wong… - Pharmacological …, 2008 - Elsevier
In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …

Oncogenic functions of the transcription factor Nrf2

I Gañán-Gómez, Y Wei, H Yang… - Free Radical Biology …, 2013 - Elsevier
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that controls the expression
of a large pool of antioxidant and cytoprotective genes regulating the cellular response to …

Chemopreventive promise of targeting the Nrf2 pathway.

MS Yates, TW Kensler - Drug news & perspectives, 2007 - europepmc.org
The Kelch ECH associating protein 1-nuclear factor-E2-related factor 2-antioxidant response
element (Keap 1-Nrf2-ARE) signaling pathway regulates several protective mechanisms …

The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer

DD Zhang - Antioxidants & redox signaling, 2010 - liebertpub.com
The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …

An update of Nrf2 activators and inhibitors in cancer prevention/promotion

F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022 - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

Nrf2 and NF-κB and their concerted modulation in cancer pathogenesis and progression

I Bellezza, AL Mierla, A Minelli - Cancers, 2010 - mdpi.com
Reactive oxygen species, produced by oxidative stress, are implicated in the initiation,
promotion, and malignant conversion of carcinogenesis through activation/suppression of …

NRF2 and the Hallmarks of Cancer

MR de la Vega, E Chapman, DD Zhang - Cancer cell, 2018 - cell.com
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

[HTML][HTML] Targeting nrf2 signaling to combat chemoresistance

JH No, YB Kim, YS Song - Journal of cancer prevention, 2014 - ncbi.nlm.nih.gov
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that upregulates expression
of a battery of genes to combat oxidative and electrophilic stress. Modification of Kelch-like …

Nrf2: a potential molecular target for cancer chemoprevention by natural compounds

WS Jeong, M Jun, ANT Kong - Antioxidants & redox signaling, 2006 - liebertpub.com
One of the most prominent strategies of cancer chemoprevention might be protecting cells or
tissues against various carcinogens and carcinogenic metabolites derived from exogenous …