Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory
Cancer chemoprevention is a process of using either natural or synthetic compounds to
reduce the risk of developing cancer. Observations that NF-E2-related factor 2 (Nrf2) …
reduce the risk of developing cancer. Observations that NF-E2-related factor 2 (Nrf2) …
Dual roles of Nrf2 in cancer
A Lau, NF Villeneuve, Z Sun, PK Wong… - Pharmacological …, 2008 - Elsevier
In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …
Oncogenic functions of the transcription factor Nrf2
I Gañán-Gómez, Y Wei, H Yang… - Free Radical Biology …, 2013 - Elsevier
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that controls the expression
of a large pool of antioxidant and cytoprotective genes regulating the cellular response to …
of a large pool of antioxidant and cytoprotective genes regulating the cellular response to …
Chemopreventive promise of targeting the Nrf2 pathway.
MS Yates, TW Kensler - Drug news & perspectives, 2007 - europepmc.org
The Kelch ECH associating protein 1-nuclear factor-E2-related factor 2-antioxidant response
element (Keap 1-Nrf2-ARE) signaling pathway regulates several protective mechanisms …
element (Keap 1-Nrf2-ARE) signaling pathway regulates several protective mechanisms …
The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer
DD Zhang - Antioxidants & redox signaling, 2010 - liebertpub.com
The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …
An update of Nrf2 activators and inhibitors in cancer prevention/promotion
F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022 - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …
factor that defends against endogenous or exogenous stressors. By inducing several …
Nrf2 and NF-κB and their concerted modulation in cancer pathogenesis and progression
I Bellezza, AL Mierla, A Minelli - Cancers, 2010 - mdpi.com
Reactive oxygen species, produced by oxidative stress, are implicated in the initiation,
promotion, and malignant conversion of carcinogenesis through activation/suppression of …
promotion, and malignant conversion of carcinogenesis through activation/suppression of …
NRF2 and the Hallmarks of Cancer
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …
Though recognized originally as a target of chemopreventive compounds that help prevent …
[HTML][HTML] Targeting nrf2 signaling to combat chemoresistance
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that upregulates expression
of a battery of genes to combat oxidative and electrophilic stress. Modification of Kelch-like …
of a battery of genes to combat oxidative and electrophilic stress. Modification of Kelch-like …
Nrf2: a potential molecular target for cancer chemoprevention by natural compounds
One of the most prominent strategies of cancer chemoprevention might be protecting cells or
tissues against various carcinogens and carcinogenic metabolites derived from exogenous …
tissues against various carcinogens and carcinogenic metabolites derived from exogenous …