Background Non-surgical chronic wounds, including diabetes-related foot diseases (DRFD),
pressure injuries (PIs) and venous leg ulcers (VLU), are common hard-to-heal wounds …

A hard-to-heal wound does not usually progress through the normal wound repair process
and remains in an inflammatory state. The aetiology of a hard-to-heal wound may be varied …

Abstract Background Diabetic foot ulcers (DFUs) account for the majority of all limb
amputations and hospitalizations due to diabetes complications. With 30 million cases of …

Abstract Purpose of Review Diabetes mellitus may affect every third adult American by 2050,
and about one-third will develop a diabetic foot ulcer (DFU) during their lifetime. The current …

Background Infected diabetic foot ulcers (IDFU) are a major complication of diabetes
mellitus. These potentially limb-threatening ulcers are challenging to treat due to impaired …

Background The aim of this study was to characterise the microbiome of new and recurrent
diabetic foot ulcers using 16S amplicon sequencing (16S AS), allowing the identification of a …

Biology research has developed considerably since next-generation sequencing (NGS)
technology was created in 2005. Since then, NGS has been widely applied clinically while …

Background: Accurate identification of primary pathogens in foot infections remains
challenging due to the diverse microbiome. Conventional culture may show false-positive or …

The extent to which microorganisms impair wound healing is an ongoing controversy in the
management of chronic wounds. Because the high diversity and extreme variability of the …

Background Health-care professionals need to collect wound samples to identify potential
pathogens that contribute to wound infection. Obtaining appropriate samples from diabetic …