Many symptoms of human depressive disorders are also observed in animals after exposure
to unpredictable stressors. The chronic mild stress (CMS) paradigm was developed in order …

The chronic mild stress (CMS) paradigm was developed in order to simulate in animals the
symptom of anhedonia, a major feature of depression. Typically, changes in hedonic status …

Chronic exposure to mild unpredictable stress (CMS) has previously been found to depress
the consumption of a weak (1%) sucrose solution by rats. This effect was confirmed in each …

Chronic exposure to mild unpredictable stress (CMS) has previously been found to
decrease hedonic responsiveness, as measured by the consumption of palatable sweet …

Chronic exposure to mild unpredictable stressors (CMS) has previously been found to
reduce the consumption of palatable, sweet solutions in rats. In the present study, the utility …

Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in rats that
resembles some of the symptoms of endogenous depression in humans. In the present …

Background In a substantial proportion of depressed patients, stressful life events play a role
in triggering the evolution of the illness. Exposure to stress has effects on different levels in …

Anhedonia, a core symptom of clinical depression, refers to the loss of interest in normally
rewarding stimuli; the chronic mild stress paradigm, an animal model of depression, was …

Depression in humans is associated with sleep abnormalities of three types: altered rapid
eye movement (REM) sleep, fragmented sleep, and reduced delta sleep. In an animal model …

The chronic mild stress (CMS) procedure was developed in rodents to target anhedonia, the
core symptom of depressive melancholia. Stress exposure has been shown to induce a …