[HTML][HTML] Mechanisms regulating intestinal barrier integrity and its pathological implications

C Chelakkot, J Ghim, SH Ryu - Experimental & molecular medicine, 2018 - nature.com
The gastrointestinal tract is a specialized organ in which dynamic interactions between host
cells and the complex environment occur in addition to food digestion. Together with the …

[PDF][PDF] The intestinal barrier function and its involvement in digestive disease

E Salvo Romero, C Alonso Cotoner… - Rev Esp Enferm …, 2015 - online.reed.es
The gastrointestinal mucosal surface is lined with epithelial cells representing an effective
barrier made up with intercellular junctions that separate the inner and the outer …

Role of barrier integrity and dysfunctions in maintaining the healthy gut and their health outcomes

S Panwar, S Sharma, P Tripathi - Frontiers in Physiology, 2021 - frontiersin.org
Mucosal surface layers are the critical borders throughout epithelial membranes. These
epithelial cells segregate luminal material from external environments. However, mucosal …

Epithelial barriers in homeostasis and disease

AM Marchiando, WV Graham… - Annual Review of …, 2010 - annualreviews.org
Epithelia form barriers that are essential to life. This is particularly true in the intestine, where
the epithelial barrier supports nutrient and water transport while preventing microbial …

The intestinal epithelial barrier: a therapeutic target?

MA Odenwald, JR Turner - Nature reviews Gastroenterology & …, 2017 - nature.com
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions

RM Catalioto, CA Maggi… - Current medicinal …, 2011 - ingentaconnect.com
The intestinal epithelial monolayer constitutes a physical and functional barrier between the
organism and the external environment. It regulates nutrients absorption, water and ion …

Regulation of intestinal epithelial permeability by tight junctions

T Suzuki - Cellular and molecular life sciences, 2013 - Springer
The gastrointestinal epithelium forms the boundary between the body and external
environment. It effectively provides a selective permeable barrier that limits the permeation …

Implication of intestinal barrier dysfunction in gut dysbiosis and diseases

C Stolfi, C Maresca, G Monteleone, F Laudisi - Biomedicines, 2022 - mdpi.com
The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

[HTML][HTML] Disruption of the epithelial barrier during intestinal inflammation: Quest for new molecules and mechanisms

S Lechuga, AI Ivanov - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
The intestinal epithelium forms a key protective barrier that separates internal organs from
the harmful environment of the gut lumen. Increased permeability of the gut barrier is a …

Cell biology of tight junction barrier regulation and mucosal disease

A Buckley, JR Turner - Cold Spring Harbor perspectives …, 2018 - cshperspectives.cshlp.org
Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a
selectively permeable barrier that supports nutrient absorption and waste secretion while …