ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A …
J Chen, M Ye, J Bai, Z Gong, L Yan, D Gu, C Hu… - Journal of Translational …, 2023 - Springer
The process of post-transcriptional regulation has been recognized to be significantly
impacted by the presence of N 6-methyladenosine (m6A) modification. As an m6A …
impacted by the presence of N 6-methyladenosine (m6A) modification. As an m6A …
ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner
W Wang, Q Huang, Z Liao, H Zhang, Y Liu, F Liu… - … Hematology & Oncology, 2023 - Springer
Abstract Background N6-methyladenosine (m6A) is a prevalent modification of mRNA and is
known to play important roles in tumorigenesis in many types of cancer. The function of N6 …
known to play important roles in tumorigenesis in many types of cancer. The function of N6 …
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
Y Chen, Y Zhao, J Chen, C Peng, Y Zhang, R Tong… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m 6 A) modification is an emerging layer of
epigenetic regulation which is widely implicated in the tumorigenicity of hepatocellular …
epigenetic regulation which is widely implicated in the tumorigenicity of hepatocellular …
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
B Tang, Y Yang, M Kang, Y Wang, Y Wang, Y Bi, S He… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal types of cancer with extremely poor
diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic …
diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic …
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
X Guo, K Li, W Jiang, Y Hu, W Xiao, Y Huang, Y Feng… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m6A) is the most abundant reversible
methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This …
methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This …
N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation
Z Zhang, L Wang, L Zhao, Q Wang… - Clinical and …, 2022 - Wiley Online Library
Background As the most widespread mRNAs modification, N6‐methyladenosine (m6A) is
dynamically and reversibly modulated by methyltransferases and demethylases. ALKBH5 is …
dynamically and reversibly modulated by methyltransferases and demethylases. ALKBH5 is …
RNA demethylase ALKBH5 inhibits TGF‐β‐induced EMT by regulating TGF‐β/SMAD signaling in non‐small cell lung cancer
Z Sun, Z Su, Z Zhou, S Wang, Z Wang… - The FASEB …, 2022 - Wiley Online Library
Abstract AlkB homolog 5 (ALKBH5) has been revealed as a key RNA N6‐methyladenosine
(m6A) demethylase that is implicated in development and diseases. However, the function of …
(m6A) demethylase that is implicated in development and diseases. However, the function of …
[HTML][HTML] ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m6A-dependent …
H Wang, S Zhao, H Liu, Y Liu, Z Zhang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Background: N6-methyladenosine (m 6 A) is the most common and abundant mRNA
modification, playing an essential role in biological processes and tumor development …
modification, playing an essential role in biological processes and tumor development …
N6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis
Pancreatic differentiation from human pluripotent stem cells (hPSCs) provides promising
avenues for investigating development and treating diseases. N 6-methyladenosine (m6A) …
avenues for investigating development and treating diseases. N 6-methyladenosine (m6A) …
[HTML][HTML] m6A demethylase ALKBH5 maintains stemness of intrahepatic cholangiocarcinoma by sustaining BUB1B expression and cell proliferation
Y Gao, M Yu, Z Liu, Y Liu, Z Kong, C Zhu, X Qin… - Translational …, 2024 - Elsevier
ALKBH5 plays critical roles in various cellular processes via post-transcriptional regulation
of oncogenes or tumor suppressors in an N6-methyladenosine (m6A)-dependent manner …
of oncogenes or tumor suppressors in an N6-methyladenosine (m6A)-dependent manner …