Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated
cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease …

Truncating variants in TTN (TTNtvs) are the most common known cause of nonischemic
dilated cardiomyopathy (DCM), but how TTNtvs cause disease has remained controversial …

Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are
also encountered in∼ 1% of the general population, where they may be silent, perhaps …

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an
abundant structural, sensory, and signaling filament in muscle) as a common cause of end …

TTN gene truncating variants are common in dilated cardiomyopathy (DCM), although data
on their clinical significance is still limited. We sought to examine the frequency of truncating …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and
heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent …

Abstract Aims Truncating titin variants (TTNtv) are the most prevalent genetic cause of
dilated cardiomyopathy (DCM). We aim to study clinical parameters and long-term outcomes …

Heart failure (HF) is a complex clinical syndrome defined by the inability of the heart to pump
enough blood to meet the body's metabolic demands. Major causes of HF are …

Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants
(TTNtvs)] are the most common genetic cause for dilated cardiomyopathy (DCM), a major …

Background The titin gene (TTN) encodes the largest human protein, which plays a central
role in sarcomere organization and passive myocyte stiffness. TTN truncating mutations …