The main hallmark of myocardial substrate metabolism in cardiac hypertrophy or heart
failure is a shift from fatty acid oxidation to greater reliance on glycolysis. However, the close …

The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms
to tightly couple fuel supply with energy demand across a wide range of physiologic and …

Background: We previously showed that cardiomyocyte Krϋppel-like factor (KLF) 5 regulates
cardiac fatty acid oxidation. As heart failure has been associated with altered fatty acid …

The Krüppel-like factors (KLFs) belong to a subclass of Cys2/His2 zinc-finger DNA-binding
proteins. The KLF family member KLF11 is originally identified as a transforming growth …

Glucocorticoids through activation of the Glucocorticoid receptor (GR) play an essential role
in cellular homeostasis during physiological variations and in response to stress. Our …

Hepatic lipogenesis is nutritionally regulated (ie, downregulated during fasting and
upregulated during the postprandial state) as an adaptation to the nutritional environment …

The metabolic myocardium is an omnivore and utilizes various carbon substrates to meet its
energetic demand. While the adult heart preferentially consumes fatty acids (FAs) over …

Background: Hypertrophic response to pathological stimuli is a complex biological process
that involves transcriptional and epigenetic regulation of the cardiac transcriptome. Although …

Although there is an increasing understanding of the signaling pathways that promote
cardiac hypertrophy, negative regulatory factors of this process have received less attention …

Skeletal muscle is a major determinant of systemic metabolic homeostasis that plays a
critical role in glucose metabolism and insulin sensitivity. By contrast, despite being a major …