The quest for effective, selective and nontoxic nucleic‐acid‐based drugs has led to
designing modifications of naturally occurring nucleosides. A number of modified nucleic …

The development of SELEX (Selective Enhancement of Ligands by Exponential Enrichment)
provides a powerful tool for the search of functional oligonucleotides with the ability to bind …

RNA or DNA aptamers with 2′-OMe-modifications have been pursued to increase
resistance to nucleases, but have been difficult to identify because the OMe groups ablate …

A modified nucleoside triphosphate bearing two modifications based on a 2′-deoxy-2′-
fluoro-arabinofuranose sugar and a uracil nucleobase equipped with a C5-ethynyl moiety (5 …

We describe herein a method for isolating fully-modified 4′-thioRNA aptamers against
human α-thrombin using the SELEX protocol. In order to isolate the desired aptamers, in …

Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production,
low cost and high chemical stability when compared with antibodies. However, the …

Nucleic acid aptamers are small oligonucleotides that specifically bind to other molecules
through noncovalent interactions that rely on complex tridimensional structural …

In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma
companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides …

The enzymatic co-polymerization of modified nucleoside triphosphates (dN* TPs and N*
TPs) is a versatile method for the expansion and exploration of expanded chemical space in …

Nucleoside triphosphates are moldable entities that can easily be functionalized at various
locations. The enzymatic polymerization of these modified triphosphate analogues …