[HTML][HTML] Functional characterization of the dural sinuses as a neuroimmune interface

J Rustenhoven, A Drieu, T Mamuladze, KA de Lima… - Cell, 2021 - cell.com
Despite the established dogma of central nervous system (CNS) immune privilege,
neuroimmune interactions play an active role in diverse neurological disorders. However …

Advances in meningeal immunity

R Rua, DB McGavern - Trends in molecular medicine, 2018 - cell.com
The central nervous system (CNS) is an immunologically specialized tissue protected by a
blood–brain barrier. The CNS parenchyma is enveloped by a series of overlapping …

The CNS immune landscape from the viewpoint of a T cell

S Mundt, M Greter, A Flügel, B Becher - Trends in neurosciences, 2019 - cell.com
Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but
also appear to influence brain development and homeostasis. During immune surveillance …

Distinct roles of the meningeal layers in CNS autoimmunity

A Merlini, M Haberl, J Strauß, L Hildebrand… - Nature …, 2022 - nature.com
The meninges, comprising the leptomeninges (pia and arachnoid layers) and the
pachymeninx (dura layer), participate in central nervous system (CNS) autoimmunity, but …

Revisiting the mechanisms of CNS immune privilege

A Louveau, TH Harris, J Kipnis - Trends in immunology, 2015 - cell.com
Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …

[HTML][HTML] Meningeal tertiary lymphoid tissues and multiple sclerosis: a gathering place for diverse types of immune cells during CNS autoimmunity

NB Pikor, A Prat, A Bar-Or, JL Gommerman - Frontiers in immunology, 2016 - frontiersin.org
Collections of leukocytes in the meningeal space have been documented in Multiple
Sclerosis (MS). These meningeal aggregates, which in the context of other autoimmune …

The meninges: new therapeutic targets for multiple sclerosis

AE Russi, MA Brown - Translational Research, 2015 - Elsevier
The central nervous system (CNS) largely comprises nonregenerating cells, including
neurons and myelin-producing oligodendrocytes, which are particularly vulnerable to …

Immune dynamics in the CNS and its barriers during homeostasis and disease

MW Buckley, DB McGavern - Immunological reviews, 2022 - Wiley Online Library
The central nervous system (CNS) has historically been viewed as an immunologically
privileged site, but recent studies have uncovered a vast landscape of immune cells that …

Multifaceted interactions between adaptive immunity and the central nervous system

J Kipnis - Science, 2016 - science.org
Neuroimmunologists seek to understand the interactions between the central nervous
system (CNS) and the immune system, both under homeostatic conditions and in diseases …

The anatomical and cellular basis of immune surveillance in the central nervous system

RM Ransohoff, B Engelhardt - Nature Reviews Immunology, 2012 - nature.com
The central nervous system (CNS) comprises the brain, spinal cord, optic nerves and retina,
and contains post-mitotic, delicate cells. As the rigid coverings of the CNS render swelling …