Background: There are methodological ambiguities in the literature on mesh refinement
analysis for computational fluid dynamics (CFD) modeling of physiologically realistic airflow …

Increased computational resources provide new opportunities to explore sophisticated
respiratory modelling. A survey of recent publications showed a steady increase in the …

During the past decades, numerous computational fluid dynamics (CFD) studies,
constructed from CT or MRI images, have simulated human nasal models. As compared to …

Respiratory physiology and pathology are strongly dependent on the airflow inside the nasal
cavity. However, the nasal anatomy, which is characterized by complex airway channels and …

Background: Knowledge of the regional deposition of inhaled particles in the nose is
important for drug delivery and assessment of the toxicity of inhaled materials. In this study …

Background: Intranasal medication is commonly used for nasal disease. However, there are
no clear specifications for intranasal medication delivery after functional endoscopic sinus …

Abstract Generating anatomically realistic 3‐dimensional (3D) models of the human
sinonasal cavity for numerical investigations of sprayed drug transport presents a host of …

Background Computational fluid dynamic (CFD) simulations have greatly improved the
understanding of nasal physiology. We postulate that simulating the entire and repeated …

Abstract Objectives/Hypothesis: Intranasal medications are commonly used in treating nasal
diseases. However, technical details of their correct administration are unclear. Methods: A …

A critical factor affecting the accuracy of Computational Fluid Dynamic (CFD) simulations
and the time required to conduct them is construction of the computational mesh. This study …