Studies of four novel diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro
E Pettersson - European journal of pharmacology, 1995 - Elsevier
Four novel diphenylbutylpiperazinepyridyl derivatives (FG5865 (2-[4-[4, 4-bis (4-
fluorophenyl) butyl]-1-piperazinyl]-3-pyridinecarboxamide), FG5891 (2-[4-[4, 4-bis (4 …
fluorophenyl) butyl]-1-piperazinyl]-3-pyridinecarboxamide), FG5891 (2-[4-[4, 4-bis (4 …
Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system
M Kimura, T Masuda, K Yamada, M Mitani… - Bioorganic & medicinal …, 2003 - Elsevier
A new series of diphenyl piperazine derivatives containing the phenyl substituted
aminopropanol moiety, which were modified at sites between the diphenyl and piperazine …
aminopropanol moiety, which were modified at sites between the diphenyl and piperazine …
Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake
RE Heikkila, L Manzino - European journal of pharmacology, 1984 - Elsevier
Abstract Two aryl 1, 4-dialkylpiperazines (GBR 12909 and GBR 13098) and one aryl 1, 4-
diakenylpiperazine (GBR 13069) were very potent inhibitors of [3 H] dopamine uptake in …
diakenylpiperazine (GBR 13069) were very potent inhibitors of [3 H] dopamine uptake in …
GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies
E Pileblad, G Engberg - Naunyn-Schmiedeberg's archives of …, 1986 - Springer
Previous in vitro studies have suggested that GBR 13098 (1-(2-(bis (4-fluophenyl methoxy)
ethyl)-4-(3-(4-fluorophenyl)-propyl) piperazine) dimethane sulfonate) acts as a selective …
ethyl)-4-(3-(4-fluorophenyl)-propyl) piperazine) dimethane sulfonate) acts as a selective …
[Pharmacological effects of the novel dopamine uptake inhibitor 1-[2-[bis (4-fluorophenyl)-methoxy] ethyl]-4-(3-phenylpropyl) piperazine dihydrochloride (I-893) on the …
The effects of 1-[2-[bis (4-fluorophenyl) methoxy] ethyl]-4-(3-phenylpropyl) piperazine
dihydrochloride (I-893) on the central nervous system were behaviorally and …
dihydrochloride (I-893) on the central nervous system were behaviorally and …
Effects of 4-(3-indolyl-alkyl) piperidine derivatives on uptake and release of noradrenaline, dopamine and 5-hydroxytryptamine in rat brain synaptosomes, rat heart …
G Le Fur, A Uzan - Biochemical Pharmacology, 1977 - Elsevier
(3-Indolyl-alkyl) piperidine derivatives (LM 5005, LM 5008, LM 5015) strongly inhibited 5-HT
accumulation into rat brain synaptosomes and human blood platelets in vitro but were …
accumulation into rat brain synaptosomes and human blood platelets in vitro but were …
Expansion of structure− activity studies of piperidine analogues of 1-[2-(diphenylmethoxy) ethyl]-4-(3-phenylpropyl) piperazine (GBR 12935) compounds by altering …
AK Dutta, MC Davis, XS Fei, PM Beardsley… - Journal of medicinal …, 2002 - ACS Publications
A series of substituted N-benzyl analogues of the dopamine transporter (DAT) specific
compound, 4-[2-(diphenylmethoxy) ethyl]-1-benzylpiperidine were synthesized and …
compound, 4-[2-(diphenylmethoxy) ethyl]-1-benzylpiperidine were synthesized and …
Definition of the In‐vivo Binding of [3H]Spiperone in Rat Brain Using Substituted Benzamide Drugs
JK Chivers, C Reavill, P Jenner… - Journal of pharmacy …, 1989 - Wiley Online Library
The ability of some substituted benzamide drugs to define in‐vivo the binding of [3H]
spiperone to brain dopamine receptors in rats was assessed using behaviourally effective …
spiperone to brain dopamine receptors in rats was assessed using behaviourally effective …
GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo
JJ Bonnet, J Costentin - European journal of pharmacology, 1986 - Elsevier
The effects of GBR 12783, an aryl 1, 4-dialk (en) ylpiperazine derivative, were studied on the
in vivo and ex vivo neuronal uptake of dopamine (DA), norepinephrine (NE) and serotonin …
in vivo and ex vivo neuronal uptake of dopamine (DA), norepinephrine (NE) and serotonin …
3-(Methyleneaminoxy) methylpiperidine derivatives as uptake inhibitors of biogenic amines in the brain synaptosomal fraction
A Balsamo, A Lapucci, A Lucacchini, M Macchia… - European journal of …, 1994 - Elsevier
Abstract A series of 3-(methyleneaminoxy) methylpiperidines (5a–h) and their
corresponding N-methyl derivatives (6a–h) with a variety of substituents on the imino carbon …
corresponding N-methyl derivatives (6a–h) with a variety of substituents on the imino carbon …
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- rat brain reuptake of dopamine
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- release of noradrenaline piperidine derivatives
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- dopamine uptake pharmacological effects
- methylpiperidine derivatives uptake inhibitors
- release of noradrenaline indolyl alkyl
- dopamine uptake behavioral properties
- release of noradrenaline blood platelets
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- biogenic amines uptake inhibitors
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- rat brain benzamide drugs