Novel benzo five-membered heterocycle derivatives as P-glycoprotein inhibitors: design, synthesis, molecular docking, and anti-multidrug resistance activity
Z Yang, Y Cai, X Yang, Y Li, Q Wu, Y Yu… - Journal of Medicinal …, 2023 - ACS Publications
A proposed strategy to overcome multidrug resistance (MDR) of anticancer drugs in
chemotherapy is to disable the efflux function of P-glycoprotein (P-gp). In this study, based …
chemotherapy is to disable the efflux function of P-glycoprotein (P-gp). In this study, based …
Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell
Z Yang, X Yang, Y Li, Y Cai, Y Yu, W Zhuang… - European Journal of …, 2023 - Elsevier
The co-administration of anticancer drugs and P-glycoprotein (P-gp) inhibitors was a
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR …
YS Li, X Yang, DS Zhao, Y Cai, Z Huang, R Wu… - European Journal of …, 2021 - Elsevier
Abstract P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a phenomenon in
which cells become resistant to structurally and mechanistically unrelated drugs resulting in …
which cells become resistant to structurally and mechanistically unrelated drugs resulting in …
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance
AA Titov, M Niso, M Candia, MS Kobzev… - Future medicinal …, 2019 - Taylor & Francis
Aim: Enamino 3-benzazecine compounds, incorporating the C6-C8 allene system, were
synthesized and evaluated in vitro as inhibitors of P-glycoprotein (P-gp) and/or multidrug …
synthesized and evaluated in vitro as inhibitors of P-glycoprotein (P-gp) and/or multidrug …
Design, synthesis and biological evaluation of N-(4-(2-(6, 7-dimethoxy-3, 4-dihydroisoquinolin-2 (1H)-yl) ethyl) phenyl)-4-oxo-3, 4-dihydrophthalazine-1-carboxamide …
Q Qiu, J Zhou, W Shi, M Kairuki, W Huang, H Qian - Bioorganic Chemistry, 2019 - Elsevier
The overexpression of P-glycoprotein plays an important role in the process of multidrug
resistance (MDR). P-gp inhibitors are one of the effective strategies to reverse tumor MDR …
resistance (MDR). P-gp inhibitors are one of the effective strategies to reverse tumor MDR …
Structure− activity relationship study of novel 2-aminobenzofuran derivatives as P-glycoprotein inhibitors
CY Chen, CM Lin, HC Lin, CF Huang, CY Lee… - European Journal of …, 2017 - Elsevier
Abstract Treatment of cancer patients with chemotherapeutic drugs is often associated with
the occurrence of tumors with a multidrug resistance (MDR). Furthermore, the relation …
the occurrence of tumors with a multidrug resistance (MDR). Furthermore, the relation …
Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell
Z Yang, D Luo, C Shao, H Hu, X Yang, Y Cai… - European Journal of …, 2024 - Elsevier
The inhibition of P-glycoprotein (P-gp) has emerged as an intriguing strategy for
circumventing multidrug resistance (MDR) in anticancer chemotherapy. In this study, we …
circumventing multidrug resistance (MDR) in anticancer chemotherapy. In this study, we …
Tetrahydroquinolinone derivatives as potent P-glycoprotein inhibitors: design, synthesis, biological evaluation and molecular docking analysis
P-glycoprotein (P-gp) is a transmembrane efflux pump that has been associated with
ineffective cancer chemotherapy and multidrug resistance (MDR). Chemical inhibitors of P …
ineffective cancer chemotherapy and multidrug resistance (MDR). Chemical inhibitors of P …
Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells
M Kairuki, Q Qiu, M Pan, Q Li, J Zhou, H Ghaleb… - Bioorganic & Medicinal …, 2019 - Elsevier
Multidrug resistance (MDR) refers to the cross-resistance of cancer cells to one drug,
accompanied by other drugs with different mechanisms and structures, which is one of the …
accompanied by other drugs with different mechanisms and structures, which is one of the …
Design and evaluation of dibenzoazepine-tetrahydroisoquinoline hybrids as potential P-glycoprotein inhibitors against multidrug resistant K562/A02 cells
C Jiang, T Pan, Y Jiang, Z Zhang, M Zeng, S Sun… - European Journal of …, 2023 - Elsevier
Multidrug resistance (MDR) caused by P-glycoprotein (P-gp) is a main barrier to the success
of cancer chemotherapies. In this study, fourteen novel dibenzoazepine …
of cancer chemotherapies. In this study, fourteen novel dibenzoazepine …