DNA structure is a critical element in determining its function. The DNA molecule is capable
of adopting a variety of non-canonical structures, including three-stranded (ie triplex) …

The ability to target specific sequences of DNA through oligonucleotide-based triple-helix
formation provides a powerful tool for genetic manipulation. Under experimental conditions …

Oligonucleotides offer enormous potential for manipulating gene function in cells and, as
such, constitute a promising new class of pharmaceutical agents. Oligonucleotides that form …

Triplex-forming oligonucleotides (TFOs) have gained prominence in the recent years
because of their potential applications in antigene therapy. In particular they have been …

Triplex-forming oligonucleotides (TFOs) can bind to the major groove of homopurine–
homopyrimidine stretches of double-stranded DNA in a sequence-specific manner through …

Triplex-forming oligonucleotides (TFOs) can bind to polypurine/polypyrimidine regions in
DNA in a sequence-specific manner. The specificity of this binding raises the possibility of …

Triplex‐forming oligonucleotides (TFOs) that can bind to duplex DNA in a sequence‐specific
manner are potential tools to achieve targeted gene modification. Initial studies …

Sequence-specificity is the key to effective genetic targeting. With specificity, targeted genes
can be manipulated in multiple ways; without it, gene therapy agents become loose canons …

Since the first description of the canonical B-form DNA double helix, it has been suggested
that alternative DNA, DNA–RNA, and RNA structures exist and act as functional genomic …

DNA is a strikingly flexible molecule and can form a variety of secondary structures,
including the triple helix, which is the subject of this review. The DNA triplex may be formed …